Objectif
The neural assembly underlying the formation of functional networks in the cerebral cortex constitutes one of the most complex neuronal systems in the brain. Much of this complexity arises during development through the interaction of two distinct neuronal types, the glutamatergic projection neurons and g-aminobutyric containing (GABAergic) interneurons. Recently, interneuron dysfunction has been associated with severe neurological and psychiatric disorders (e.g. epilepsy, schizophrenia and bipolar disorder). In order to achieve true progress in the understanding of cortical development and of neurological diseases associated with cortical interneuron dysfunction, a complete account of the development of its neuronal constituents is essential. In that sense, despite the detailed picture that is emerging about the development of cortical projection neurons, the mechanisms underlying the development of interneurons in the cerebral cortex have remained poorly defined. The general goal of the network is to obtain a comprehensive definition of the cellular and molecular mechanisms controlling the development of cortical interneurons. To reach this aim, we will take a multidisciplinary approach by combining novel bioinformatic and genomics applications, cutting-edge imaging techniques, and conventional cellular, molecular and electrophysiological methodologies. In addition, we will develop new genetic tools to engineer developmental models of cortical disorders involving interneuron deficiency. Thus, successful execution of the project will result in: i) New knowledge of the mechanisms underlying the specification, migration and terminal differentiation of cortical interneurons, and ii) Generation of new developmental models of cortical disorders resulting from interneuron deficiency.
Champ scientifique
Mots‑clés
Appel à propositions
FP6-2003-LIFESCIHEALTH-I
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Régime de financement
STREP - Specific Targeted Research ProjectCoordinateur
MADRID
Espagne