Objective
Hepatocellular carcinoma (HCC) causes about 500,000 deaths worldwide each year and is the leading cause of cancer mortality in some parts of the world. Although the pathogens for HOC are quite clear, the molecular mechanisms through which they induce HOC development still need to be clarified. AP-1 genes encode transcription factors, which possibly play important roles in many cancers, including HOC.
Until now, little is known about their functions in liver carcinogenesis. In this respect, I will investigate AP-1 functions in genotoxiccarcinogen induced HCC using conditional knock-out mice. This study will focus on c-Jun, c-Fos and p53pathways and their interactive functions in liver cancer, especially in the early stages of carcinogenesis. Molecules responsible f or dysregulated apoptosis and proliferation will be identified by molecular, immunohistological and micro-array analyses.
This project will uncover novel insights into the molecular mechanisms involved in HCC, which may provide new avenues for the development of diagnostic and drug targets in the future.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology liver cancer
- social sciences sociology demography mortality
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
VIENNA
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.