Final Activity Report Summary - AFALC (Analysing the functions of AP-1 in liver carcinogenesis)
On the other hand, JNK1, but not JNK2, is essential for mouse liver cancer development. In addition, my results also showed that c-Jun promotes survival of initiated liver cancer cells by repressing c-Fos expression. Taken together, my data strongly indicate that the JNK/c-Jun pathway is a valuable target for liver cancer therapy.