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Analyzing the functions of AP-1 in liver carcinogenesis

Final Activity Report Summary - AFALC (Analysing the functions of AP-1 in liver carcinogenesis)

I have been studying the roles of MAPKs (p38alpha and JNK1/2) and AP-1 (c-Jun and c-Fos) in liver cancer development. Using a chemical-induced cancer model, I found that p38alpha suppresses proliferation of cancer cells by antagonising the JNK/c-Jun pathway.

On the other hand, JNK1, but not JNK2, is essential for mouse liver cancer development. In addition, my results also showed that c-Jun promotes survival of initiated liver cancer cells by repressing c-Fos expression. Taken together, my data strongly indicate that the JNK/c-Jun pathway is a valuable target for liver cancer therapy.