Objective
Cancer is today one of the biggest death threats to European citizens. For many years chemotherapy has been one of the most useful tools against cancer. Organometallic chemistry offers novel concepts in structural diversity and molecular recognition that c an be used in drug design. The objective of this project is to design and synthesise novel metal-based drugs that interact with the target, DNA, by an induced-fit mechanism. This interaction will be recognised by nuclear proteins. The applicant will investigate the role of the DNA-metallodrug-protein interactions that leads to cell death and its consequences in the treatment of cancer.
The host institution is well equipped with state-of-the-art equipment and facilities for the proposed project either directly within the School of Chemistry in Edinburgh or the Centres associated with the School of Chemistry, e.g. Edinburgh Protein Interaction Centre (EPIC), Institute for Cell and Molecular Biology (ICMB), Scottish Centre for Genomic Technology and Informatics ( GTI), Collaborative Optical Spectroscopy and Micromanipulation Centre (COSMIC) and the Cancer Research UK Centre at the Western General Hospital. The success of this project will ultimately help Europe to compete at the highest international level in the field, and will increase European attractiveness to overseas researchers.
The mobility to the host country under supervision of Prof. Sadler and the visits to the laboratories of Prof. Sadler's European collaborators', e.g. Prof. Sava in Trieste and Prof. Bra becin Brno, will provide the applicant with a unique training for an independent future career in academia or industry. The programme will provide the researcher with links for future cooperation, an opportunity to acquire new cutting edge skills, to participate in multicultural research teams and to experience the benefits of cultural diversity. The applicant will develop an international profile in her career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences chemical sciences inorganic chemistry organometallic chemistry
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics spectroscopy
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.