Objective
A major factor that affects the emergence and survival of resistant strains is the biological cost of resistance. Thus, to reduce the rate of spread of resistant bacteria we need to identify antibiotic targets and antibiotics for which the resistance mecha nisms have the most negative effects on bacterial fitness. Thus, the overall aims of this proposal are to experimentally examine and define in several medically important species how fitness, virulence and transmission are affected by different types of an tibiotic resistance. Such knowledge is a prerequisite for: (i) predicting the rate and stability of resistance development, (ii) developing novel diagnostic test systems for resistant bacterial clones with a high risk of resistance development, (iii) forec asting the value of intervention strategies and (iv) rational design of antibiotics and choice of antibiotic targets where the potential for resistance development is minimized. We intend to address in eight different work packages the following questions. 1. How does different resistance mechanims affect bacterial fitness and physiology (WP1-3)? 2. How can the fitness costs of antibiotic resistance be genetically compensated (WP3)? 3. How does different resistance mechanims affect transmission rates in ani mal models (WP4), volunteers (WPS) and clinical settings (WP6)? 4. Can thew prevalence of antibiotic resistance be reduced in human populations by lowering the volume of use of antibiotics (WP7)? 5. Can antibiotics and targets be rationally chosen such tha t the rate of resistance development is minimized (WP8)?
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences basic medicine physiology
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
UPPSALA
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.