Objective
Spinal cord injuries (SCI) have long been regarded as intractable, largely due to the alleged inability of the mammalian CMS to regenerate. However, over the last two decades, technological advances combined with the understanding of the pathophysiology of SCI have progressed to the point where it is now conceivable to develop therapeutic intervention strategies aimed at reconstructing the neuronal circuitry damaged by the lesion. One of the most powerful tools for this objective is based on stem cells, whi ch can be used in three different ways to achieve this goal: 1) to bring permissive molecules and/or trophic agents at the level of the lesion to enhance the regenerative capacity of severed axons; 2) to use as replacement cells, grafted locally to stimula te specific circuits such as the central pattern generator (CPG); 3) to enhance the reparative potential of intrinsic stem cells. Most of the program will concentrate on human adult stem cells generated from bone marrow and adult CNS (including the spinal cord), but we will also consider foetal stem cells and established cell lines. Rodent cells will also be used as a model. This program will be achieved in three steps: Harvesting of adult and/or foetal stem cells (neural and non-neural), to be used directl y or after transformation through genetic engineering. Grafting in the injured cord. Monitoring of the grafted cells with in vivo imaging, and assessing their effects using functional studies. It will require several technical prerequisites including stand ardisation for the harvesting of human stem cells, for the spinal cord lesion models, for the transplantation paradigms and for the functional studies. The final objective of the present project is the translation of experimental studies to clinical practi ce through the elaboration of a series of therapeutic tools to be used in a wide variety of clinical paradigms of SCI.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences medical biotechnology genetic engineering gene therapy
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MONTPELLIER
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.