Objective
Posttranscriptional events must play a more central role in generating the highly complex proteomes of metazoa than previously believed. This is shown by the large discrepancy between the number of coding sequences of metazoan genomes and the known diversi ty of gene products that they generate. Indeed, alternative pathways for processing the primary transcript of a gene can theoretically generate more transcripts and, ultimately, more protein variants (i.e. isoforms) than the number of classically defined genes in an entire organism. Thus, the process of alternative splicing can greatly expand the information content of genomes. Alternative splicing is an essential component of gene regulation, affecting every aspect of eucaryotic biology, and understanding the mechanisms that lead to alternatively spliced transcripts is essential for the functional interpretation of genomic sequences. In addition, a large number of genetic diseases are caused by defects in the proper processing of primary transcripts, and a lterations in alternative splicing are the basis for multiple human pathologies including cancer, viral infection and inflammatory responses. Despite its prevalence and significance, the molecular mechanisms that regulate alternative splicing are poorly un derstood. The EURASNET consortium employs a wide range of complementary approaches as computational, biochemical, proteomic, genomic, cell and organismal biology to study post-transcriptional gene regulation and its role in disease. The primary purpose of this network will be to develop an integrated approach for the study of alternative splicing that will 1 ) provide durable structures that change the way research in this field is carried out in Europe, 2) establish an innovative and multidisciplinary prog ramme of joint research activities, 3)spread excellence within Europe by establishing a career platform for young investigators, and 4) disseminate knowledge to the wider research and medical
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- medical and health sciencesclinical medicineoncology
- medical and health sciencesbasic medicinepathology
- natural sciencesbiological sciencesgeneticsgenomes
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Topic(s)
Call for proposal
FP6-2004-LIFESCIHEALTH-5
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Funding Scheme
NoE - Network of ExcellenceCoordinator
MUENCHEN
Germany
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Participants (31)
BARCELONA
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ERLANGEN
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256 UPPSALA
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102209 HEIDELBERG
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39040 TEL AVIV
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TRIESTE
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VIENNA
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EDINBURGH
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ROMA
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GIESSEN
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PARIS
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BERN
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DUNDEE
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LONDON
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LISBOA
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LEICESTER
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POZNAN
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AARHUS C
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BUENOS AIRES
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GENEVA 4
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DUNDEE
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CAMBRIDGE
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JERUSALEM
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10142 ILLKIRCH
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PARIS
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MILANO
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GENEVA 4
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ZUERICH
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WARSAW
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BARCELONA
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SOUTHAMPTON SO17 1BJ
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