Objetivo Model organisms are essential to study the genetic basis of human diseases. Transgenic mammalian models, especially genetic knock-out mice catalysed the progress. To continue the advancement, further sophisticated and refined models are crucially needed to study the genetic basis and manifestations of numerous human diseases. In order to enhance our genetic understanding of human diseases, this proposal is aimed to develop new tools for the generation of transgenic laboratory animal models both in mouse and rat for comparative analyses of functional genomics in different species. In the mouse stable embryonic stem cell lines enable gene-targeting technology. However, the lack of such cell lines in most mammalians has so far prevented targeted genetic modifications.This proposal is aimed to use new tools such as nuclear replacement and gene targeting in somatic cells as a technological platform for producing new transgenic models. The primary aim is to further explore and validate the nuclear replacement system for safety and reliability as a technological platform. Our goal is also to generate the first gene targeted rat models. Relevant issues, such as the role of mitochondrial inheritance, somatic cell gene targeting and standardisation of newly generated genotypes by cryo-preservation will be addressed as well. Ámbito científico medical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cells Programa(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Tema(s) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Convocatoria de propuestas FP6-2004-LIFESCIHEALTH-5 Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador AGRICULTURAL BIOTECHNOLOGY CENTER Aportación de la UE Sin datos Dirección Szent Gyorgyi Albert utca 4. GODOLLO Hungría Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo BIOTALENTUM LTD. Hungría Aportación de la UE Sin datos Dirección Aulich Lajos 26 GÖDÖLLO Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH) Alemania Aportación de la UE Sin datos Dirección Ingolstaedter Landstrasse 1 NEUHERBERG Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITY OF COPENHAGEN Dinamarca Aportación de la UE Sin datos Dirección Noerregade 10 COPENHAGEN K Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITY OF NOTTINGHAM Reino Unido Aportación de la UE Sin datos Dirección University Park NOTTINGHAM Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITY OF VETERINARY MEDICINE, VIENNA Austria Aportación de la UE Sin datos Dirección Veterinaerplatz 1 VIENNA Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos