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Estrogens and women ageing

Objective

In women estrogens and their cognate receptors regulate reproductive activities and exert protective functions in skeletal, cardiovascular and nervous systems. With the increased life expectancy women spend now more than one third of their life in menopause, a physiological state in which ovaries stop producing sexual hormones. To date risks and benefits of post-menopause hormone replacement therapy (HRT) are still unclear. Indeed, clinical results are in strong conflict with experimental results, the latter showing a clear protective effect of estrogens against bone, vessel, skin and brain malfunctions.

EWA will build on existing knowledge, reagents and infrastructures landmarks of European excellence in estrogen research to focus on:
a) generation of innovative cell and animal models for the identification of the safest compounds to be used in HRT;
b) ascertainment of the therapeutic efficacy and risks of known and novel molecules to be used for HRT;

Call for proposal

FP6-2004-LIFESCIHEALTH-5
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Coordinator

UNIVERSITÀ DEGLI STUDI DI MILANO
Address
Via Festa Del Perdono, 7
Milano
Italy

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Participants (7)

THE UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
Manchester

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EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstr. 1
Heidelberg

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CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Serrano 117
Madrid

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CONSORTIUM FOR RESEARCH, PREVENTION AND TREATMENT OF METABOLIC AND ENDOCRINE DISEASES
Italy
Address
Via Kramer 4/a
Milano

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KAROLINSKA INSTITUET
Sweden
Address
Nobelsväg 5
Stockholm

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HORMOS MEDICAL CORPORATION
Finland
Address
Itainen Pitkakatu 4b
Turku

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CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE - GROUPEMENT D'INTERET ECONOMIQUE
France
Address
1 Rue Laurent Fries
10142 Illkirch

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