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INTEGRATING GENOMICS-BASED APPLICATIONS TO EXPLOIT ACTINOMYCETES AS A RESOURCE FOR NEW ANTIBIOTICS

Objective

ActinoGEN is an integrated project aimed at developing novel genomics-based approaches to exploit hitherto overlooked genetic resources for new antibiotics. Drug discovery will focus on (1) accessing new antibiotic biosynthetic pathways from diverse actinomycetes that have yet to be cultured; (2) activating cryptic pathways from well-characterised actinomycetes; and (3) engineering novel hybrid antibiotics by combinatorial biosynthesis. To greatly accelerate the drug discovery process, a parallel strategy will be to engineer generic hosts optimised to produce high antibiotic yields. With the complete genome sequence of the model actinomycete, Streptomyces coelicolor, and mobilization of a pan-European effort to apply newly developed multidisciplinary post-genomic technologies, a holistic understanding of the physiology and regulation of antibiotic biosynthesis is achievable for the first time. This will, in turn, permit rational intervention to engineer generic hosts for high-yield antibiotic production. This synergy of discovery linked to overproduction will place the European biotechnology sector at the forefront of developing much-needed new antibiotics to combat multi-drug resistant pathogens.

Call for proposal

FP6-2003-LIFESCIHEALTH-I
See other projects for this call

Coordinator

UNIVERSITY OF WALES, SWANSEA
Address
Singleton Park
Swansea

Participants (17)

DIPARTIMENTO DI BIOLOGIA CELLULARE E DELLO SVILUPPO, UNIVERSITA DI PALERMO
Address
Viale Delle Scienze - Parco D'orleans Ii'
Palermo
EBERHARD KARLS-UNIVERSITÄT TÜBINGEN
Address
Wilhelmstrasse 5
Tuebingen
ENTRECHEM SL
Address
Centro De Empresas Del Caudal
Mieres
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Address
147, Rue De L'universite
Paris
INSTITUTE OF BIOTECHNOLOGY OF LEÓN
Address
C/real No 1
Leon
INSTITUTE OF MICROBIOLOGY, ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
Address
Videnska 1083
Prague
JOHN INNES CENTRE
Address
Norwich Research Park
Norwich
LIBRAGEN
Address
11 Avenue Einstein
Villeurbanne
RIJKSUNIVERSITEIT GRONINGEN
Address
Broerstraat 5
Groningen
SEOUL NATIONAL UNIVERSITY
Address
56-1 Shinlim-dong, Kwanak-ku
Seoul
TECHNICAL UNIVERSITY OF DENMARK
Address
Anker Engelunds Vej 1
Kgs. Lyngby
TECHNISCHE UNIVERSITAET BERLIN
Address
Strasse Des 17. Juni
Berlin
THE UNIVERSITY OF MANCHESTER
Address
Oxford Road
Manchester
UNIVERSIDAD DE OVIEDO
Address
San Francisco, 3
Ovideo
UNIVERSITE PARIS-SUD
Address
Rue Georges Clemenceau
Orsay
UNIVERSITY OF SURREY
Address
University Campus
Guildford
UNIVERSITY OF WARWICK
Address
Gibbet Hill Road
Coventry