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RNA Interference Technology as Human Therapeutic Tool

Objective

The RIGHT project aims at exploiting the vast potential of RNA interference (RNAi) for human therapy, based on an advanced understanding of the underlying mechanisms. Rational and selective approaches will be taken to generate efficient RNAi reagents, and strategies will be developed for efficient delivery to cells and tissues of diseased organisms. RIGHT combines the strengths of 5 synergistic competence domains to reach this ambitious goal and overcome key technological barriers such as undesired interferon response and insufficient delivery, stability and targeting of RNAi to the appropriate cells. 1. The understanding of the molecular processes associated with RNAi and microRNA will be improved as a basis for the development of molecular strategies and tools enabling the successful application of RNAi for human therapy. 2. Improved inhibitors including RNAi mimics and potent delivery reagents will be chemically synthesized and extensively tested in cell culture and living organisms in order to increase sensitivity, specificity and cost-effectiveness and reduce side effects. 3. Potent viral or non-viral RNAi vectors will be generated and their features evaluated in relation to their chemical counterparts. 4. For the development of a drug, synthetic or genetic RNAi reagents will be assessed with pharmacokinetic methods, and extensive phenotyping of treated animals will be performed. 5. Selected disease models will be used for the paradigmatic assessment of RNAi as a therapeutic tool to generate RNAi leads for clinical tests. The RIGHT partnership of leading research institutions and biotech SMEs will deliver tools such as new enabling technologies, chemically synthesized and genetically generated inhibitors with efficient delivery properties. Within 4 years, the potential of RNAi to diagnose and successfully treat severe unvanquished diseases will be demonstrated and proof of principle provided for the value of RNAi as a therapeutic tool in living organisms.

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Coordinator

MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V
Address
Hofgartenstrasse 8
101062 Muenchen
Germany

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Participants (26)

UNIVERSITY OF AARHUS
Denmark
Address
Nordre Ringgade 1
Aarhus C

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VTT TECHNICAL RESEARCH CENTRE OF FINLAND
Finland
Address
Vuorimiehentie 5
1000 Espoo

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UNIVERSITY OF SOUTHERN DENMARK
Denmark
Address
Campusvej 55
Odense M

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UNIVERSITY OF UPPSALA
Sweden
Address
Husargatan 3
581 Uppsala

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Tour Europa 126
Thiais

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UNIVERSITY OF TURIN
Italy
Address
Via Verdi 8
Torino

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REGULON, SA
Greece
Address
Grigoriou Afxentiou 7, Alimos
Athens

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LUDWIG-MAXIMILIANS UNIVERSITAET MUENCHEN
Germany
Address
Geschwister-scholl-platz 1
Munich

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DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ)
Germany
Address
Im Neuenheimer Feld 280
Heidelberg

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JOHANN WOLFGANG GOETHE-UNIVERSITÄT FRANKFURT AM MAIN
Germany
Address
Senckenberganlage 31
111 932 Frankfurt

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KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
Oude Markt 13
Leuven

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FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
Address
Via Olgettina 60
Milan

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INSTITUTE OF BIOORGANIC CHEMISTRY, POLISH ACADEMY OF SCIENCES
Poland
Address
Noskowskiego 12/14
Poznan

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RINA-NETZWERK RNA TECHNOLOGIEN GMBH
Germany
Address
Takustr. 3
Berlin

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UNIVERSITY OF ROME "LA SAPIENZA"
Italy
Address
P.le A.moro 5
Rome

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Links
CENTRE EUROPÉEN POUR LA RECHERCHE EN BIOLOGIE ET MÉDECINE - GROUPEMENT D'INTÉRÊT ECONOMIQUE
France
Address
1 Rue Laurent Fries
10142 Illkirch

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BIOMEDICAL SCIENCES RESEARCH CENTER "ALEXANDER FLEMING"
Greece
Address
34, Fleming Str., Vari
74145 - GR1660 Athens

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POLYPLUS TRANSFECTION SAS
France
Address
Bd Sebastien Brant
BP 90018 Illkirch

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ARTTIC
France
Address
58a, Rue Du Dessous Des Berges
Paris

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RIBOTASK APS
Denmark
Address
Sdr. Boulevard 44, 3
Odense

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UNIVERSITY OF THE WITWATERSRAND
South Africa
Address
1 Jan Smuts Avenue
Private Bag 3 Braamfontein, Johannesburg

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INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
101 Rue De Tolbiac
Paris

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HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF - UNIVERSITÄTSKLINIKUM
Germany
Address
Moorenstrasse 5
Düsseldorf

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UNIVERSITY OF UTRECHT
Netherlands
Address
Heidelberglaan 8
Utrecht

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Links
ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE
Switzerland
Address
Epfl P-pres, Ce 3 316, Station 1
Lausanne

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Links
MACROZYME B.V.
Netherlands
Address
Meibergdreef 45
Amsterdam

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