Objective
During tumour progression, proliferating tumour cells lose their polarized epithelial phenotype, acquire an invasive phenotype and metastasize to other organs in the body. These processes frequently kill the cancer patient, however, little is currently known about the mechanisms that underlie tumour invasion and metastasis. To discover how cells develop an invasive phenotype, we will study epithelial plasticity, with particular focus on epithelial-to-mesenchymal transition (EMT) both in vitro and in vivo. We will identify the signalling pathways and genes involved and determine how they are regulated and their specific functions. We will then use this information to determine the importance of these processes in carcinoma progression and metastasis. We aim to define new targets for cancer therapy and novel markers for diagnosis and prognosis. The training objectives of this interdisciplinary network are to expose young researchers at the PhD and postdoctoral level to advanced techniques and new concepts that will help them become future leaders in cancer research.
Cancer research is a highly challenging and multifaceted discipline. It is essential that cancer researchers have at their disposal a very wide range of techniques from a number of different disciplines, in particular, biochemistry, cell biology, molecular biology, developmental biology and tumour biology. Our objective is to train the young researchers in as many of these areas as possible through the network. None of the individual labs use all of these approaches, but through secondments, exchanges between the labs and network meetings, the young researchers will be able to become expert in many of these disciplines.
Furthermore, flexibility and independence will be stimulated by exposing the researchers to foreign culture and language as well as to different schools of scientific thought. After participating in the network they will be ready to take on demanding jobs in European academia and industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology skin cancer squamous cell carcinoma
- natural sciences biological sciences cell biology
- natural sciences biological sciences developmental biology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.