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PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood

Objective

Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The goal of PanCareLIFE is that survivors of cancer diagnosed before age 25 should enjoy the same quality of life and opportunities as their peers who have not had cancer. Using observational studies and molecular genetic investigations PanCareLIFE will investigate late effects that impact fertility and hearing impairment (ototoxicity), and will assess health-related quality of life. Information from PanCareLIFE’s studies will be incorporated into new guidelines for fertility preservation. As the number of survivors with late effects in any one country is small, large cohorts are required for accurate estimation of risk. PanCareLIFE has assembled a team of prominent investigators from 8 European countries who will contribute in total over 12,000 well-characterised research subjects to identify risk factors, both genetic and non-genetic, linked to decrements in fertility and ototoxicity. Quality-of-life studies will evaluate the impact of fertility and ototoxicity. PanCareLIFE will advance the state-of-the-art in survivorship studies by evaluation of large cohorts with observational and genetic tools that will provide better knowledge of individual risk factors. Survivors can then be stratified into groups benefitting from personalized, evidence-based, care; future patients may expect effective therapies to have less severe side effects, and plans for a seamless transition to long-term follow-up care can be made. These approaches will result in better quality of life for survivors of cancer diagnosed at a young age.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
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Coordinator

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Address
Langenbeckstrasse 1
55131 Mainz
Germany

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Silvia Tschauder (Dr.)
EU contribution
€ 911 972,55

Participants (19)

BOYNE RESEARCH INSTITUTE LIMITED
Ireland
EU contribution
€ 304 040,45
Address
Duke Street Duke House Unit One
A92 RY6K Drogheda

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Activity type
Research Organisations
Administrative Contact
Julianne Byrne (Dr.)
PINTAIL LTD
Ireland
EU contribution
€ 159 007,85
Address
Springhill Avenue 77
A94 K542 Blackrock

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ciaran Clissmann (Mr.)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 437 430,46
Address
Meibergdreef 15
1105AZ Amsterdam

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Georgiev Sylvia (Ms.)
UNIVERSITATSKLINIKUM ERLANGEN

Participation ended

Germany
Address
Maximiliansplatz 2
91054 Erlangen

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katrin Faber (Dr.)
STICHTING VU

Participation ended

Netherlands
EU contribution
€ 199 081,16
Address
De Boelelaan 1105
1081 HV Amsterdam

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eline Van Dulmen-Den Broeder (Dr.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 1 093 948,80
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ellen Schenk (Dr.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 195 529,92
Address
Chariteplatz 1
10117 Berlin

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Ms.)
Westfälische Wilhelms-Universität Münster
Germany
EU contribution
€ 414 934,93
Address
Schlossplatz 2
48149 Muenster

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Julija Winschel (Mrs.)
UNIVERSITAET BERN
Switzerland
EU contribution
€ 270 973,79
Address
Hochschulstrasse 6
3012 Bern

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Claudia Kuehni (Prof.)
ISTITUTO GIANNINA GASLINI
Italy
EU contribution
€ 199 988,61
Address
Via Gerolamo Gaslini 5
16147 Genova

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Maria Gabriella Marinari (Dr.)
FAKULTNI NEMOCNICE BRNO
Czechia
EU contribution
€ 194 348,04
Address
Jihlavska 20
625 00 Brno

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Activity type
Research Organisations
Administrative Contact
Tomas Kepak (Dr.)
CENTRE HOSPITALIER UNIVERSITAIRE SAINT ETIENNE - CHU
France
EU contribution
€ 127 820,34
Address

42055 Saint Etienne

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Claire Berger (Dr.)
KRAEFTENS BEKAEMPELSE
Denmark
EU contribution
€ 99 608,80
Address
Strandboulevarden 49
2100 Koebenhavn

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Activity type
Research Organisations
Administrative Contact
Jeanette Falck Winther (Dr.)
FAKULTNI NEMOCNICE V MOTOLE
Czechia
EU contribution
€ 194 644,40
Address
V Uvalu 84
150 06 Praha 5

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Activity type
Research Organisations
Administrative Contact
Jarmila Kruseova (Dr.)
UNIVERSITAET zu LUEBECK
Germany
EU contribution
€ 390 426,42
Address
Ratzeburger Allee 160
23562 Lubeck

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gabriele Kipke
PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Netherlands
Address
Heidelberglaan 25
3584CS Utrecht

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Activity type
Other
Administrative Contact
Menno Berens (Mr.)
UNIVERSITATSKLINIKUM BONN
Germany
EU contribution
€ 388 020,24
Address
Venusberg-campus 1
53127 Bonn

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Becker (Mrs.)
STICHTING VUMC
Netherlands
EU contribution
€ 397 603,49
Address
De Boelelaan 1117
1081 HV Amsterdam

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Activity type
Research Organisations
Administrative Contact
Yvonne Koppelman (Mrs.)
UNIVERSITAETSKLINIKUM ESSEN
Germany
EU contribution
€ 18 898,75
Address
Hufelandstrasse 55
45147 Essen

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sebastian George (Mr.)