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Targets and biomarkers for antiepileptogenesis

Objective

Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a combinatorial approach is necessary to identify appropriate biomarkers and develop effective antiepileptogenic therapeutics. The project will focus on identifying novel biomarkers and their combinations for epileptogenesis after potentially epileptogenic brain insults in clinically relevant animal models, such as traumatic brain injury (TBI) and status epilepticus (SE); explore multiple basic mechanisms of epileptogenesis and their mutual interactions related to cell degeneration, circuit reorganization, inflammatory processes, free radical formation, altered neurogenesis, BBB dysfunction, genetic and epigenetic alterations; and translating these findings towards the clinic by validating biomarkers identified from animal models in human post TBI brain tissue and blood samples, post-mortem brain tissue in individuals that died soon after SE, and human brain and blood samples from chronic epilepsy cases. The project will identify novel combinatorial biomarkers and novel disease-modifying combinatorial treatment strategies for epileptogenesis, create an Epilepsy Preclinical Biobank, and validate translational potential of results from animal models in human tissue. To adequately address the proposed goals, the project will develop technological breakthroughs, such as completely novel chemogenetic approaches, novel MRI techniques, novel multimodal organic recording devices for simultaneous recordings of EEG / cellular unit activity and biochemical measurements, novel bioluminescence for in vivo promoter activity analysis, and novel systems biology approaches.

Field of science

  • /medical and health sciences/basic medicine/neurology/epilepsy

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

MAX IV Laboratory, Lund University
Address
Paradisgatan 5C
22100 Lund
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 077 141
Administrative Contact
Merab Kokaia (Prof.)

Participants (19)

LIFE AND BRAIN GMBH
Germany
EU contribution
€ 500 000
Address
Venusberg-campus 1
53127 Bonn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Heinz Beck (Prof.)
MICROVITAE TECHNOLOGIES SAS
France
EU contribution
€ 495 300
Address
Avenue D Armenie Polo D Activite Y Morandat 1480
13120 Gardanne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thierry Hervé (Dr.)
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 1 045 000
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Reinikainen (Ms.)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 687 500
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
Administrative Contact
Maria Grazia Pezzoni (Ms.)
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 523 620
Address
Bunteweg 2
30559 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Joppe (Mr.)
University College London
United Kingdom
EU contribution
€ 1 481 344
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kamila Kolasinska (Ms.)
UNIVERSITATSKLINIKUM BONN
Germany
EU contribution
€ 642 000
Address
Venusberg-campus 1
53127 Bonn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Becker (Ms.)
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 352 000
Address
Ul. Ludwika Pasteura 3
02 093 Warszawa
Activity type
Research Organisations
Administrative Contact
Marta Rucinska (Mrs.)
UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 530 540
Address
Boulevard Charles Livon 58
13284 Marseille
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Céline Damon (Ms.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 672 599
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
UNIVERSITA DEGLI STUDI DI FERRARA
Italy
EU contribution
€ 475 000
Address
Via Ariosto 35
44121 Ferrara
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dario Di Luca (Prof.)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 645 480
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gulseren Yalvac (Ms.)
BEN-GURION UNIVERSITY OF THE NEGEV
Israel
EU contribution
€ 399 980
Address
.
84105 Beer Sheva
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daphna Tripto (Ms.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation ended

Germany
EU contribution
€ 130 525
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Mrs.)
BIOVIRON SARL
France
EU contribution
€ 399 214
Address
Rue Marcelin Berthelot 5
69680 Chassieu
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hervé Berthommé (Dr.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 406 655
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Dittrich (Mr.)
TO-BBB TECHNOLOGIES BV

Participation ended

Netherlands
EU contribution
€ 133 311
Address
Jh Oortweg 19
2333 CH Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sijme Zeilemaker (Mr.)
NANOMERICS LTD
United Kingdom
EU contribution
€ 46 800
Address
Euro House 1394 High Road
N20 9YZ London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andreas G. Schatzlein (Prof.)
ARTTIC
France
EU contribution
€ 355 966
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Dietz (Dr.)