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MicroRNAs in the Pathogenesis, Treatment and Prevention of Epilepsy

Objective

Epilepsy is a major burden for patients and health systems worldwide. It is a common chronic neurological disorder affecting people of all ages, and the shortfall in existing treatments means that 30% of patients continue to suffer uncontrolled seizures. MicroRNAs (miRNA) are a recently-discovered, network-level layer of gene expression regulation that controls protein levels of entire signaling pathways. Research on miRNAs has unprecedented potential to (i) further our understanding of the underlying disease processes, (ii) deliver novel signatures and prognostic markers for response to therapy, and (iii) deliver novel therapeutics and drug targets. EpiMiRNA consortium members have pioneered discoveries on brain-specific miRNAs, established that miRNA changes are a feature of the pathophysiology of human temporal lobe epilepsy and have demonstrated experimentally that altering miRNA function can potently suppress epileptic seizures and seizure-damage. EpiMiRNA brings together experts on the neurobiology of miRNAs with the leading researchers working on miRNAs in epilepsy, epilepsy geneticists, leaders in miRNA-target detection, proteomics, and systems biology with research-intensive SMEs pursuing miRNA therapeutics and treatments for pharmacoresistant epilepsy. Through highly collaborative, inter-disciplinary and inter-sectorial research, EpiMiRNA will explain the mechanism by which miRNAs contribute to epileptogenesis, characterize genetic variation of miRNA in patients, evaluate seizure-suppressing effects of miRNAs in experimental models, identify novel miRNA modulatory molecules as potential future therapeutics, and develop miRNAs as prognostic markers to identify patients who respond to novel, non-pharmacological therapeutic interventions including brain stimulation. EpiMiRNA will generate the necessary critical mass in biomedical, clinical and industry/SME research to track, treat and prevent seizures and improve the clinical management of epilepsy patients.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Coordinator

ROYAL COLLEGE OF SURGEONS IN IRELAND
Address
Saint Stephen's Green 123
2 Dublin
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 418 033
Administrative Contact
David Henshall (Prof.)

Participants (18)

PHILIPPS UNIVERSITAET MARBURG
Germany
EU contribution
€ 2 887 839
Address
Biegenstrasse 10
35037 Marburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margret Keller (Ms.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 526 180
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jeroen Pasterkamp (Dr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 418 085
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephanie Schorge (Dr.)
UNIVERSITA DEGLI STUDI DI VERONA
Italy
EU contribution
€ 399 540
Address
Via Dell Artigliere 8
37129 Verona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paolo Fabene (Prof.)
UNIVERSITATSKLINIKUM ERLANGEN
Germany
EU contribution
€ 599 740
Address
Maximiliansplatz 2
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Faber Katrin (Dr.)
DUKE UNIVERSITY

Participation ended

United States
EU contribution
€ 271 856
Address
Allen Building 207
27708 Durham Nc
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cherie Lathi (Ms.)
UNIVERSIDADE ESTADUAL DE CAMPINAS
Brazil
EU contribution
€ 380 660
Address
Cidade Universitaria Zeferino Sn
13083 875 Campinas Sp
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Iscia Lopes-Cendes (Prof.)
AARHUS UNIVERSITET
Denmark
EU contribution
€ 548 310
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rikke Schultz Gjerulff (Mrs.)
SYDDANSK UNIVERSITET
Denmark
EU contribution
€ 620 000
Address
Campusvej 55
5230 Odense M
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jens Andersen (Prof.)
DIXI MICROTECHNIQUES SAS

Participation ended

France
EU contribution
€ 156 977,29
Address
Chemin De Palente 4 Espace
25025 Besancon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jean-Pierre Darnis (Mr.)
CERBOMED GMBH
Germany
EU contribution
€ 232 800
Address
Henkestrasse 91
91052 Erlangen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jens Ellrich (Prof.)
INTERNA TECHNOLOGIES BV
Netherlands
EU contribution
€ 319 383
Address
Jonkerbosplein 52
6534 AB Nijmegen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roel Schaapveld (Dr.)
BICOLL GMBH
Germany
EU contribution
€ 449 880
Address
Richard Riemerschmid Allee 27
81241 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kai Lamottke (Dr.)
BIOCOMPUTING PLATFORMS LTD OY
Finland
EU contribution
€ 303 900
Address
Innopoli 3 Vaisalantie 6
02130 Espoo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anita Eliasson (Ms.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation ended

Germany
EU contribution
€ 182 102
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Mrs.)
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
United States
EU contribution
€ 433 356
Address
Amsterdam Avenue 1210 Room
10027 7003 New York
Activity type
Higher or Secondary Education Establishments
Administrative Contact
William Berger (Mr.)
ARTTIC
France
EU contribution
€ 307 898
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Dietz (Dr.)
DIXI MEDICAL
France
EU contribution
€ 130 318,71
Address
2A Route De Pouligney
25640 Chaudefontaine
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jean-Pierre Darnis (Mr.)