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Taking imaging into the therapeutic domain: Self-regulation of brain systems for mental disorders

Objective

Our proposal is based on the idea that real-time functional neuroimaging can be used to train patients to regulate their own brain activity via neurofeedback training and thus modulate the brain networks of mental disorder, restore function, improve symptoms and promote resilience. We have brought together the core groups that have been instrumental in the development of methods for real-time functional imaging and fMRI (functional magnetic resonance)-based neurofeedback and have led the initial clinical applications in neuropsychiatric disorders. Our proposal has three main components, the development and refinement of methods for the real-time analysis and feedback of fMRI data and combination with other imaging modalities (WP2), the adaptation of fMRI mapping techniques to localise disease-relevant networks and development of protocols for their self-regulation through neurofeedback (WP3) and the assessment of feasibility and clinical effects in several mental disorders that are characterised by dysfunctional brain systems for motivation, emotion regulation and social communication and by important therapeutic gaps (autism spectrum disorders, alcohol addiction, post-traumatic stress disorder, childhood anxiety disorders, binge-eating disorder) (WP4). We will also explore the potential transfer of (laboratory-based) imaging feedback training into everyday settings through ambulatory and assistive technologies such as electroencephalography (EEG) and gaming (WP5). We will engage with potential users of these technologies (healthcare professionals and providers, medical instrument and software manufacturers, patient and carer associations) through several workshops, liaise with regulatory authorities and disseminate findings to the academic and user communities in WP6.

Field of science

  • /medical and health sciences/clinical medicine/psychiatry/anxiety disorders

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

CARDIFF UNIVERSITY
Address
Newport Road 30-36
CF24 ODE Cardiff
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 028 241,01

Participants (12)

INSERM TRANSFERT SA
France
EU contribution
€ 409 831
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 508 000
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
TEL AVIV UNIVERSITY
Israel
EU contribution
€ 666 000
Address
Ramat Aviv
69978 Tel Aviv
Activity type
Higher or Secondary Education Establishments
UNIVERSIDADE DE COIMBRA
Portugal
EU contribution
€ 638 000
Address
Paco Das Escolas
3001 451 Coimbra
Activity type
Higher or Secondary Education Establishments
University College London

Participation ended

United Kingdom
EU contribution
€ 240 509,32
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 103 058
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
BRAIN INNOVATION BV
Netherlands
EU contribution
€ 1 752 000
Address
Oxfordlaan 55
6229 EV Maastricht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITEIT TWENTE
Netherlands
EU contribution
€ 55 458
Address
Drienerlolaan 5
7522 NB Enschede
Activity type
Higher or Secondary Education Establishments
THALES NEDERLAND BV
Netherlands
EU contribution
€ 69 099
Address
Zuidelijke Havenweg 40
7554 RR Hengelo Ov
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 186 000
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
THE FOUNDATION FOR MEDICAL RESEARCH INFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV
Israel
EU contribution
€ 45 000
Address
Weizmann Street 6
64239 Tel Aviv
Activity type
Research Organisations
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 297 464,67
Address
Hofgartenstrasse 8
80539 Munich
Activity type
Other