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A drug strategy targeting stabilised mutant p53 to fight metastatic platinum-resistant ovarian cancer

Objective

"Epithelial ovarian cancer (EOC) is the most lethal gyncaecological malignancy causing 41900 deaths annually in Europe. The predominance of aggressive Type II tumours, which are characterised by a high frequency of p53 mutations, and primary or acquired resistance to platinum-based chemotherapy profoundly contribute to the high mortality rate. With current standard therapy the median overall survival of metastatic platinum-resistant (Pt-R) ovarian cancer patients is only 14 month. There is a pressing need for more effective, innovative treatment strategies to particularly improve survival in this subgroup of EOC patients. The GANNET53 trial aims to achieve this goal by applying a highly innovative concept that has grown from solid basic research findings made by members of the GANNET53 consortium. This is a drug strategy targeting a central driver of tumour aggressiveness and metastatic ability, namely mutant p53, via an innovative new Hsp90 (heat shock protein 90) inhibition mechanism. The most advanced, second-generation Hsp90 inhibitor will be used, Ganetespib. The first part (Phase I) of the GANNET53 trial will test the safety of Ganetespib in a new combination with standard chemotherapy (Paclitaxel weekly) in Pt-R Type II EOC patients. The second part (randomised Phase II) will examine the efficacy of Ganetespib in combination with standard chemotherapy versus standard chemotherapy alone in EOC patients with Pt-R Type II tumours. We established a highly efficient consortium with previously proven capability and manpower to perform this multicentre clinical trial and assess our innovative therapeutic concept in this deadly disease. Our consortium consists of national clinical trial groups in gynaecological oncology and high-volume University centres as well as noted p53 scientists and 3 innovative SMEs. Since ovarian cancer is defined as a rare cancer a scale at the European level is crucial for the planned clinical trial."

Field of science

  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

MEDIZINISCHE UNIVERSITAT INNSBRUCK
Address
Christoph Probst Platz 1
6020 Innsbruck
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 564 140
Administrative Contact
Nicole Concin (Prof.)

Participants (17)

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 371 489
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elke Lammertyn (Dr.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 700 011
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Ms.)
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 161 655
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sven Mahner (Dr.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 465 989
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Wolf Husslein (Prof.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 287 250
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Alix Pillot (Ms.)
CENTRE DE LUTTE CONTRE LE CANCER LEON BERARD
France
EU contribution
€ 197 715
Address
Rue Laennec 28
69373 Lyon
Activity type
Research Organisations
Administrative Contact
Isabelle Ray-Coquard (Dr.)
AGO RESEARCH GMBH
Germany
EU contribution
€ 198 562
Address
Kaiser-friedrich Ring 71
65185 Wiesbaden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stefanie Barth (Mrs.)
NORD-OSTDEUTSCHE GESELLSCHAFT FUR GYNAKOLOGISCHE ONKOLOGIE EV
Germany
EU contribution
€ 136 528
Address
Augustenburger Platz 1
13353 Berlin
Activity type
Research Organisations
Administrative Contact
Jalid Sehouli (Prof.)
ARCAGY ASSOCIATION
France
EU contribution
€ 180 562
Address
Place Du Parvis Notre Dame 1
75004 Paris
Activity type
Research Organisations
Administrative Contact
Eric Pujade-Lauraine (Prof.)
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany
EU contribution
€ 371 778
Address
Robert-koch-strasse 40
37075 Goettingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christiane Hennecke (Mrs.)
ONCOLAB DIAGNOSTICS GMBH
Austria
EU contribution
€ 549 944
Address
Viktor Kaplan Strasse 2
2700 Wiener Neustadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Astrid Flandorfer (Dr.)
XAILABS GMBH
Germany
EU contribution
€ 180 474
Address
Lobeckstrasse 36
10969 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Salvatore Vanasco (Mr.)
KLINIKEN ESSEN-MITTE EVANG. HUYSSENS-STIFTUNG/KNAPPSCHAFT GEMEINNUTZIGE GMBH
Germany
EU contribution
€ 143 625
Address
Henricistrasse 92
45136 Essen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Florian Heitz (Dr.)
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 98 550
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Brenner (Mrs.)
CENTRE REGIONAL FRANCOIS BACLESSE
France
EU contribution
€ 125 595
Address
Avenue Du General Harris 3
14076 Caen Cedex 5
Activity type
Research Organisations
Administrative Contact
Florence Joly (Prof.)
UNIVERSITAET GREIFSWALD
Germany
EU contribution
€ 170 670
Address
Domstrasse 11
17489 Greifswald
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrea Völker (Dr.)
OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG
Germany
EU contribution
€ 89 535
Address
Universitaetsplatz 2
39106 Magdeburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joachim Bischoff (Dr.)