Skip to main content

Aggression subtyping for improved insight and treatment innovation in psychiatric disorders

Objective

Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental subtypes, we investigate the aetiology of maladaptive aggression in paediatric conduct disorders most strongly predisposing to pathological aggression, ADHD and conduct disorder, and in the general population. We employ highly innovative approaches in humans and animal models and maximize the output from the project by optimally balancing the use of large, existing data sets with new data acquisition. Through this, we build a knowledge chain from molecule to behaviour, investigating known and novel genes, gene-networks and their epigenetic interactions, and mapping their mode of action from the molecular via the cellular to the brain-circuit level. This is accompanied by highly powered analyses of the neural substrates of the aggression subtypes.
Based on innovative bioinformatic multimodal data integration, our interdisciplinary research will lead to novel, accurate algorithms for reliable aggression prediction, which will be validated in existing longitudinal studies in children and tested for their predictive value in adult outcome. In addition to this approach towards prevention, we test promising non-pharmacological biofeedback for personalised treatment and prevention of overt aggression. For the identification of novel pharmacological compounds in aggression treatment, we introduce a new animal model, the zebrafish.
The Aggressotype consortium is based on successful existing collaborations. It includes experts in childhood and adult psychiatry and research-intensive SMEs ensuring maximal dissemination, clinical implementation and business development opportunities.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT
Address
Houtlaan 4
6525 XZ Nijmegen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 777 771,98

Participants (25)

KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 202 160,40
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT DE BARCELONA
Spain
EU contribution
€ 61 500
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Activity type
Higher or Secondary Education Establishments
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
EU contribution
€ 80 000
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona
Activity type
Research Organisations
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT

Participation ended

Germany
EU contribution
€ 124 981,56
Address
Josef-schneider-strasse 2
97080 Wurzburg
Activity type
Higher or Secondary Education Establishments
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Germany
EU contribution
€ 478 661,60
Address
Square J 5
68159 Mannheim
Activity type
Higher or Secondary Education Establishments
UNIVERSITETET I BERGEN
Norway
EU contribution
€ 100 000
Address
Museplassen 1
5020 Bergen
Activity type
Higher or Secondary Education Establishments
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
United States
EU contribution
€ 140 000
Address
State Street 35
12201 Albany Ny
Activity type
Other
TARTU ULIKOOL
Estonia
EU contribution
€ 200 000
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF LEICESTER
United Kingdom
EU contribution
€ 255 000
Address
University Road
LE1 7RH Leicester
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 475 000
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
ISLENSK ERFDAGREINING EHF

Participation ended

Iceland
EU contribution
€ 9 792
Address
Sturlugotu 8
101 Reykjavik
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GENALICE BV
Netherlands
EU contribution
€ 200 000
Address
Deventerweg 9 G
3843GA Harderwijk
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GENOWAY
France
EU contribution
€ 100 000
Address
31 Rue Saint Jean De Dieu Technopark 2
69007 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
VIEW POINT
France
EU contribution
€ 250 000
Address
Technoparc Saone Valle
01390 Civrieux
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
University of Zurich
Switzerland
EU contribution
€ 210 000
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
Concentris Research Management GmbH
Germany
EU contribution
€ 360 000
Address
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 45 000
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF DUNDEE

Participation ended

United Kingdom
EU contribution
€ 36 276,02
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET ULM
Germany
EU contribution
€ 45 000
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 45 000
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 47 160
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
OSPEDALE PEDIATRICO BAMBINO GESU
Italy
EU contribution
€ 45 000
Address
Piazza Sant Onofrio 4
00165 Roma
Activity type
Research Organisations
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
EU contribution
€ 279 018,44
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
AARHUS UNIVERSITET
Denmark
EU contribution
€ 216 357
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
STATENS SERUM INSTITUT
Denmark
EU contribution
€ 216 321
Address
Artillerivej 5
2300 Kobenhavn S
Activity type
Research Organisations