Objective
Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental subtypes, we investigate the aetiology of maladaptive aggression in paediatric conduct disorders most strongly predisposing to pathological aggression, ADHD and conduct disorder, and in the general population. We employ highly innovative approaches in humans and animal models and maximize the output from the project by optimally balancing the use of large, existing data sets with new data acquisition. Through this, we build a knowledge chain from molecule to behaviour, investigating known and novel genes, gene-networks and their epigenetic interactions, and mapping their mode of action from the molecular via the cellular to the brain-circuit level. This is accompanied by highly powered analyses of the neural substrates of the aggression subtypes.
Based on innovative bioinformatic multimodal data integration, our interdisciplinary research will lead to novel, accurate algorithms for reliable aggression prediction, which will be validated in existing longitudinal studies in children and tested for their predictive value in adult outcome. In addition to this approach towards prevention, we test promising non-pharmacological biofeedback for personalised treatment and prevention of overt aggression. For the identification of novel pharmacological compounds in aggression treatment, we introduce a new animal model, the zebrafish.
The Aggressotype consortium is based on successful existing collaborations. It includes experts in childhood and adult psychiatry and research-intensive SMEs ensuring maximal dissemination, clinical implementation and business development opportunities.
Fields of science
Call for proposal
FP7-HEALTH-2013-INNOVATION-1
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Funding Scheme
CP-FP - Small or medium-scale focused research projectCoordinator
6525 XZ Nijmegen
Netherlands
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Participants (25)
WC2R 2LS London
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08007 Barcelona
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08035 Barcelona
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Participation ended
97080 Wurzburg
68159 Mannheim
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5020 Bergen
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12201 Albany Ny
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51005 Tartu
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LE1 7RH Leicester
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6200 MD Maastricht
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101 Reykjavik
3843GA Harderwijk
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69007 Lyon
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01390 Civrieux
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8006 Zurich
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82256 Furstenfeldbruck
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9713 GZ Groningen
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Participation ended
DD1 4HN Dundee
89081 Ulm
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08036 Barcelona
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28020 Madrid
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00165 Roma
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60323 Frankfurt Am Main
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8000 Aarhus C
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2300 Kobenhavn S
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