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DEVELOPMENT OF TAILORED ANTIMICROBIAL TREATMENT REGIMENS AND NOVEL
HOST- PATHOGEN INSIGHTS FOR RESPIRATORY TRACT INFECTIONS AND SEPSIS

Objective

Though of tremendous benefit, the overuse of antibiotics has lead to the emergence of antibiotic resistance and may cause adverse events that impact on patient healthcare. Current diagnostic tools for facilitating the appropriate use of antibiotics in patients are inadequate.

We will establish a broad-based strategy (not limited to a particular antibiotic group) that can be implemented on a broad scale to increase the effectiveness of antimicrobial therapy, reduce adverse events, and help limit the emergence of antimicrobial resistance in children and adults.

At the heart of the TAILORED-Treatment project is a prospective clinical study in which we will recruit 1200 patients (>2000 patient samples) presenting with respiratory tract infections and/or sepsis. Patient cohorts will include equal representation of genders, children and adults. State-of-the-art molecular technologies will be applied to characterize host-pathogen interactions at the genomic, transcriptomic, proteomic and clinical level, resulting in a large-scale and unique multi-dimensional dataset. The consortium partners will develop new computational tools to interrogate this data, in order to provide new insights into personalized host-pathogen interactions, including the discovery of novel biomarkers for physicians to use in patient diagnosis and disease monitoring.

Concurrently, using this data, we will construct a predictive personalized treatment algorithm that will lead to informed and personalized antimicrobial treatment regimens (indication, dosage, and duration) that are tailored to the needs (type of infection, presence of novel biomarkers etc) of children and adults presenting with respiratory infections and sepsis.

This unique multi-dimensional dataset and personalized predictive treatment algorithm will be built into an easily navigable web-based, free-to-use, decision support system for use by physicians to explore and assist in patient-tailored antimicrobial treatment decisions.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 438 430
Administrative Contact
John Hays (Dr.)

Participants (6)

IBEXPERTS Ltd.
Israel
EU contribution
€ 257 000
Address
Haalon Street 16A
43572 Raanana
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Racheli Kreisberg (Dr.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 729 987
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Louis Bont (Prof.)
HADASSAH MEDICAL ORGANIZATION
Israel
EU contribution
€ 496 381,40
Address
N/a
91120 Jerusalem
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dan Engelhard (Prof.)
MEMED DIAGNOSTICS LTD
Israel
EU contribution
€ 1 512 452,80
Address
Nahum Heth Street 5
39120 Tirat Carmel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eran Eden (Dr.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 1 012 720
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ellen Rydberg (Dr.)
NORAY BIOINFORMATICS SL
Spain
EU contribution
€ 528 411,80
Address
Parque Tecnologico 801A
48160 Derio
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva González (Dr.)