Objective Though of tremendous benefit, the overuse of antibiotics has lead to the emergence of antibiotic resistance and may cause adverse events that impact on patient healthcare. Current diagnostic tools for facilitating the appropriate use of antibiotics in patients are inadequate.We will establish a broad-based strategy (not limited to a particular antibiotic group) that can be implemented on a broad scale to increase the effectiveness of antimicrobial therapy, reduce adverse events, and help limit the emergence of antimicrobial resistance in children and adults.At the heart of the TAILORED-Treatment project is a prospective clinical study in which we will recruit 1200 patients (>2000 patient samples) presenting with respiratory tract infections and/or sepsis. Patient cohorts will include equal representation of genders, children and adults. State-of-the-art molecular technologies will be applied to characterize host-pathogen interactions at the genomic, transcriptomic, proteomic and clinical level, resulting in a large-scale and unique multi-dimensional dataset. The consortium partners will develop new computational tools to interrogate this data, in order to provide new insights into personalized host-pathogen interactions, including the discovery of novel biomarkers for physicians to use in patient diagnosis and disease monitoring.Concurrently, using this data, we will construct a predictive personalized treatment algorithm that will lead to informed and personalized antimicrobial treatment regimens (indication, dosage, and duration) that are tailored to the needs (type of infection, presence of novel biomarkers etc) of children and adults presenting with respiratory infections and sepsis.This unique multi-dimensional dataset and personalized predictive treatment algorithm will be built into an easily navigable web-based, free-to-use, decision support system for use by physicians to explore and assist in patient-tailored antimicrobial treatment decisions. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.2.3.1-2 - Stratified approaches to antibacterial and/or antifungal treatment Call for proposal FP7-HEALTH-2013-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM EU contribution € 1 438 430,00 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam Netherlands See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact John Hays (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all IBEXPERTS Ltd. Israel EU contribution € 257 000,00 Address HAALON STREET 16A 43572 RAANANA See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Racheli Kreisberg (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAIR MEDISCH CENTRUM UTRECHT Netherlands EU contribution € 729 987,00 Address HEIDELBERGLAAN 100 3584 CX Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Louis Bont (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HADASSAH MEDICAL ORGANIZATION Israel EU contribution € 496 381,40 Address N/A 91120 Jerusalem See on map Activity type Higher or Secondary Education Establishments Administrative Contact Dan Engelhard (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEMED DIAGNOSTICS LTD Israel EU contribution € 1 512 452,80 Address NAHUM HETH STREET 5 39120 TIRAT CARMEL See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eran Eden (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GOETEBORGS UNIVERSITET Sweden EU contribution € 1 012 720,00 Address VASAPARKEN 405 30 Goeteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Administrative Contact Ellen Rydberg (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NORAY BIOINFORMATICS SL Spain EU contribution € 528 411,80 Address PARQUE TECNOLOGICO 801A 48160 DERIO See on map Region Noreste País Vasco Bizkaia Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eva González (Dr.) Links Contact the organisation Opens in new window Total cost No data