Objective Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omics”-based approaches, has revealed that cancer must be considered a heterogeneous disease. Historically, “one-size-fits-all” approaches have been standard practice in CRC treatment, but with the increased understanding of the molecular/genetic heterogeneity of CRC, it is clear that novel treatments must be developed and tested in selected subgroups to maximize the benefit of these new developments. MErCuRIC is a multicentre phase Ia/b clinical trial which will assess a novel therapeutic strategy (combined treatment of a MEK inhibitor PD-0325901 or MEK-162 with a MET inhibitor PF-02341066) to combat metastasis, improve survival and change current clinical practice for CRC patients with RAS mutant (MT) and RAS wild type (WT) (with aberrant c-MET) tumours. The consortium will go beyond the current state-of-the-art by (i) employing a novel treatment strategy targeting the biology of the disease and by (ii) using next generation sequencing (NGS) and ‘xenopatients’ to identify CRC patient subgroups who will maximally benefit from this novel treatment strategy. Fields of science medical and health sciencesclinical medicineoncologycolorectal cancer Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.2.4.1-1 - Investigator-driven treatment trials to combat or prevent metastases in patients with solid cancer Call for proposal FP7-HEALTH-2013-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator THE QUEEN'S UNIVERSITY OF BELFAST EU contribution € 541 289,87 Address UNIVERSITY ROAD LANYON BUILDING BT7 1NN Belfast United Kingdom See on map Region Northern Ireland Northern Ireland Belfast Activity type Higher or Secondary Education Establishments Administrative Contact Colleen Spence (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (12) Sort alphabetically Sort by EU Contribution Expand all Collapse all FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO) Spain EU contribution € 230 040,76 Address CALLE NAZARET 115-117 08035 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Andrés De Kelety Alcaide (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 1 019 511,61 Address WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Stephen Conway (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAIR ZIEKENHUIS ANTWERPEN Belgium EU contribution € 346 183,49 Address DRIE EIKENSTRAAT 655 2650 Edegem See on map Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Research Organisations Administrative Contact Marc Peeters (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VELINDRE NATIONAL HEALTH SERVICE TRUST United Kingdom EU contribution € 42 294,42 Address Parc Nantgarw-Charnwood Court 2 CF15 7QZ Cardiff See on map Region Wales West Wales and The Valleys Central Valleys Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Richard Adams (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ROYAL COLLEGE OF SURGEONS IN IRELAND Ireland EU contribution € 222 459,57 Address ST STEPHEN'S GREEN 123 2 Dublin See on map Region Ireland Northern and Western Border Activity type Higher or Secondary Education Establishments Administrative Contact Bryan Hennessy (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Université Paris Descartes France EU contribution € 112 471,96 Address Rue de l'Ecole de Médecine 75270 cedex 06 Paris See on map Activity type Higher or Secondary Education Establishments Administrative Contact Rosaly Datchi (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI TORINO Italy EU contribution € 334 134,83 Address VIA GIUSEPPE VERDI 8 10124 Torino See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Administrative Contact Alberto Bardelli (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France EU contribution € 237 335,52 Address 55 BOULEVARD DIDEROT 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Alix Pillot (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MULTIPLICOM NV Belgium EU contribution € 72 050,76 Address GALILEILAAN 18 2845 NIEL See on map Region Vlaams Gewest Prov. 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Antwerpen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jurgen Del-Favero (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Masarykova univerzita Czechia EU contribution € 60 066,32 Address Zerotinovo namesti 9 601 77 Brno See on map Region Česko Jihovýchod Jihomoravský kraj Activity type Higher or Secondary Education Establishments Administrative Contact Katarína Hanušová (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PINTAIL LTD Ireland EU contribution € 147 001,77 Address SPRINGHILL AVENUE 77 A94 K542 Blackrock See on map Region Ireland Eastern and Midland Dublin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ciaran Clissmann (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BELFAST HEALTH AND SOCIAL CARE TRUST United Kingdom EU contribution € 93 679,60 Address LISBURN ROAD BELFAST CITY HOSPITAL A FLOOR BT9 7AS Belfast See on map Region Northern Ireland Northern Ireland Belfast Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Kate O'brien (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data