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Comparing health services interventions for the prevention of HPV-related cancer

Objective

Important progress has been made in the field of HPV-disease prevention with the development and implementation of HPV vaccines and HPV DNA screening. In the CoheaHr project, the (cost-) effectiveness of different European preventive strategies will be compared. The goal is to build a reliable and comparable evidence base on the (cost-) effectiveness of these policies implemented under country-specific preventive services conditions.

To achieve this goal, a set of specific tasks will be carried out. Three randomized trials will be performed in organised screening settings to determine: i) whether self-collection of specimens for HPV DNA testing is an effective and feasible alternative for physician-based sampling, ii) whether screening intervals can be extended in women vaccinated at young age, iii) whether vaccinating women two years before entering the screening programme will favour the use of HPV screening. The first and third randomized trials are multi-country trials whereas the second trial will be carried out in a cohort of Finnish women vaccinated in 2007. For unvaccinated, 25-45 year old women participating in screening, acceptability and general feasibility of HPV vaccination will be studied in a multi-country demonstration survey. Comparisons by transmission models are included to provide long-term projections for cancer incidence and mortality. Furthermore, the establishment of a standardised joint European data warehouse will be continued and extended for (continuous) evaluation of comparative effectiveness of screening and vaccination policies in Europe. Finally, there will be an ongoing effort for producing systematic reviews and meta-analyses which provide a sustainable resource for evidence.

CoheaHr will provide a strong evidence base which enable policy and other decision makers to make informed decision-making on HPV prevention strategies, thereby contributing to strengthening health systems and health services interventions in Europe.

Field of science

  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /social sciences/sociology/governance/public services
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

STICHTING VUMC
Address
De Boelelaan 1117
1081 HV Amsterdam
Netherlands
Activity type
Research Organisations
EU contribution
€ 1 656 706,40
Administrative Contact
Yvonne Koppelman (Mrs.)

Participants (12)

INSTITUT CATALA D'ONCOLOGIA
Spain
EU contribution
€ 735 638,30
Address
Av Gran Via De L'hospitalet 199-203
08908 L'hospitalet Del Llobregat
Activity type
Research Organisations
Administrative Contact
Cris Rajo (Mrs.)
TAMPEREEN YLIOPISTO
Finland
EU contribution
€ 1 106 850
Address
Kalevantie 4
33014 Tampere
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Airila Susanna (Mrs.)
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 142 089,70
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jack Cuzick (Prof.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 519 219,60
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Agneta Häggström (Ms.)
INSTITUT SCIENTIFIQUE DE SANTE PUBLIQUE
Belgium
EU contribution
€ 373 000
Address
Rue Juliette Wytsman 14
1050 Bruxelles
Activity type
Research Organisations
Administrative Contact
Marc Arbyn (Dr.)
AZIENDA OSPEDALIERA CITTA DELLA SALUTE E DELLA SCIENZA DI TORINO
Italy
EU contribution
€ 586 950
Address
Corso Bramante 88 90
10126 Torino
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Guglielmo Ronco (Dr.)
CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
France
EU contribution
€ 336 250,40
Address
150 Cours Albert Thomas
69372 Lyon Cedex 08
Activity type
Other
Administrative Contact
Olaf Kelm (Dr.)
UNIVERZA V LJUBLJANI
Slovenia
EU contribution
€ 142 600
Address
Kongresni Trg 12
1000 Ljubljana
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mario Poljak (Prof.)
KRAEFTENS BEKAEMPELSE
Denmark
EU contribution
€ 131 700
Address
Strandboulevarden 49
2100 Koebenhavn
Activity type
Research Organisations
Administrative Contact
Susanne Kjaer (Prof.)
UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE
France
EU contribution
€ 134 715,80
Address
Boulevard De La Paix 9 Villa Douce
51100 Reims
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nathalie Rau
STADT WOLFSBURG
Germany
EU contribution
€ 125 808
Address
Porschestrasse 49
38440 Wolfsburg
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Karl Petry (Prof.)
STICHTING VU
Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johannes Berkhof (Dr.)