Objective The infectious diseases burden imposed by the parasites of Trypanosomatidae family represents a huge problem on people’s lives in countries where these diseases are endemic. Problems associated with existing drugs include inefficient delivery, insufficient efficacy, excessive toxicity and increasing resistance. New drugs are urgently needed now and in the foreseeable future. The New Medicine for Trypanosomatid Infections (NMTrypI) consortium uses a highly interdisciplinary approach to optimize pteridine, benzothiazole and miltefosine derivatives, as well as natural products against Trypanosomatids. The lead compounds target mechanisms that are associated with protozoa virulence and pathogenicity. The major objectives of this 3-year project are: i) development of drug leads which may be used in combination with a known or an investigational drugs, by using a common drug discovery platform established by experts in their respective fields, ii) development of pharmacodynamic biomarkers enabling the proteomic profiling of compound efficacy and early identification of drug resistance. NMTrypI addresses sleeping sickness, leishmaniasis, and Chagas disease. The partners are SMEs (5) and academics (8) in Europe and in disease-endemic countries (Italy, Greece, Portugal, Sudan, and Brazil). The new platform enables high throughput screening of compound libraries, lead development, testing in relevant animal models, as well as toxicology and safety testing. NMTrypI will translate drug leads into drug candidacy through 6 scientific work packages (WPs1-6) supported by two transversal WPs dedicated to project dissemination and management. The major strength of the consortium lies in the complementary partners’expertise and the integrated platform that will provide:- at least 1-2 innovative, less toxic and safer drug candidates for Trypanosomatid infections compared to existing ones,- early phase biomarkers for efficacy prediction (overall improved efficacy and safety) Fields of science medical and health sciencesclinical medicinepsychiatrysleep disordersmedical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemedical and health sciencesbasic medicinetoxicology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.2.3.4-2 - Drug development for neglected parasitic diseases Call for proposal FP7-HEALTH-2013-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA Address Via universita 4 41121 Modena Italy See on map Region Nord-Est Emilia-Romagna Modena Activity type Higher or Secondary Education Establishments Administrative Contact Maria Paola Costi (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 889 824,31 Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all European ScreeningPort GmbH Germany EU contribution € 87 281,18 Address Schnackenburgallee 22525 Hamburg See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Philip Gribbon (Dr.) Links Contact the organisation Opens in new window Website Opens in new window BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN Germany EU contribution € 502 965,00 Address Bernhard nocht strasse 74 20359 Hamburg See on map Region Hamburg Hamburg Hamburg Activity type Research Organisations Administrative Contact Joachim Clos (Dr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC Portugal EU contribution € 469 318,80 Address Rua alfredo allen 208 4200 135 Porto See on map Region Continente Norte Área Metropolitana do Porto Activity type Research Organisations Administrative Contact Claudia Ferreira (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA DEGLI STUDI DI SIENA Italy EU contribution € 340 740,00 Address Via banchi di sotto 55 53100 Siena See on map Region Centro (IT) Toscana Siena Activity type Higher or Secondary Education Establishments Administrative Contact Stefano Mangani (Prof.) Links Contact the organisation Opens in new window Website Opens in new window HITS GGMBH Germany EU contribution € 581 808,80 Address Schloss wolfsbrunnenweg 35 69118 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Rebecca Wade (Dr.) Links Contact the organisation Opens in new window Website Opens in new window TYDOCK PHARMA S.r.l Italy EU contribution € 388 570,00 Address Strada gherbella 294/b 41126 Modena See on map Region Nord-Est Emilia-Romagna Modena Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Alberto Venturelli (Dr.) Links Contact the organisation Opens in new window Website Opens in new window NATIONAL CENTER FOR RESEARCH Sudan EU contribution € 158 860,00 Address El-mak nimir street 11111 Khartoum See on map Activity type Research Organisations Administrative Contact Adil Ahmed Abdallah (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Hypha Discovery Limited United Kingdom EU contribution € 392 793,85 Address Briar cottages, bakers lane 1 SL6 6QH Maidenhead See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gillian Charles (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ETHNIKO IDRYMA EREVNON Greece EU contribution € 447 492,19 Address Vas konstantinou 48 11635 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Administrative Contact Ioanna Petrohilou (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSIDAD COMPLUTENSE DE MADRID Spain EU contribution € 445 484,80 Address Avenida de seneca 2 28040 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Administrative Contact María Isabel Rodríguez Villa (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window INTERFACE EUROPE Participation ended Belgium EU contribution € 254 339,02 Address Rue du trône 1000 Bruxelles See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Christiane Andriamandroso (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window CENTRO NACIONAL DE PESQUISA EM ENERGIA E MATERIAS ASSOCIACAO PRIVADA Brazil EU contribution € 325 965,20 Address Rua giuseppe maximo scolfaro 10000 13083 100 Campinas See on map Activity type Research Organisations Administrative Contact Milena Francelim Camargo Links Contact the organisation Opens in new window Website Opens in new window FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germany EU contribution € 615 968,00 Address Hansastrasse 27c 80686 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Administrative Contact Michael Prestele (Mr.) Links Contact the organisation Opens in new window Website Opens in new window
