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Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies

Objective

Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has relatively rare but considerable risks. Coronary computed tomography (CT) is the most accurate diagnostic test for CAD currently available. CT may become the most effective strategy to reduce the ca. 2 million annual negative ICAs in Europe by enabling early and safe discharge of the majority of patients with an intermediate risk of CAD.
To evaluate this, we propose the DISCHARGE project that will be implemented by a multinational European consortium. The core of the project is the DISCHARGE pragmatic randomised controlled trial. The primary hypothesis will be that CT is superior to ICA for major adverse cardiovascular events (cardiovascular death, nonfatal myocardial infarction and stroke) after a maximum follow-up of 4 years in a selected broad population of stable chest pain patients with intermediate pretest likelihood of CAD. The trial will include 25 clinical sites from 16 European countries ensuring broad geographical representation. Comparative effectiveness research of complementing work packages include gender-related analysis, systematic review of evidence, cost-effectiveness analysis, and health-related quality of life. DISCHARGE has the capability to influence current standards and guidelines as well as coverage decisions and will raise awareness among patients, health care providers, and decision-makers in Europe about the effectiveness and cost-effectiveness of coronary CT angiography.

Field of science

  • /medical and health sciences/basic medicine/neurology/stroke
  • /medical and health sciences/clinical medicine/radiology/medical imaging/computed tomography

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Address
Chariteplatz 1
10117 Berlin
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 538 595
Administrative Contact
Adriane Napp (Ms.)

Participants (34)

MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 154 304
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wolfram Rieneck (Dr.)
UNIVERSITAIR ZIEKENHUIS ANTWERPEN

Participation ended

Belgium
Address
Drie Eikenstraat 655
2650 Edegem
Activity type
Research Organisations
Administrative Contact
Erlend Van Breusegem (Mr.)
FAKULTNI NEMOCNICE V MOTOLE
Czechia
EU contribution
€ 113 220
Address
V Uvalu 84
150 06 Praha 5
Activity type
Research Organisations
Administrative Contact
Josef Veselka (Prof.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 222 126
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Christine Nuding (Mrs.)
KLINIKEN DES LANDKREISES GOPPINGEN GGMBH
Germany
EU contribution
€ 130 696
Address
Eichertstrasse 3
73035 Goppingen
Activity type
Research Organisations
Administrative Contact
Stephen Schroeder (Prof.)
UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 130 696
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Matthias Gutberlet (Prof.)
SEMMELWEIS EGYETEM
Hungary
EU contribution
€ 127 320
Address
Ulloi Utca 26
1085 Budapest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bela Merkely (Prof.)
SOUTH EASTERN HEALTH AND SOCIAL CARE TRUST NHS
United Kingdom
EU contribution
€ 164 310
Address
Upper Newtownards Road Ulster Hospital Dundonald Trust Headquarters
BT16 1RH Belfast
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Paul Carlin (Mr.)
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 165 480
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Donal Doolan (Mr.)
UNIVERSITA DEGLI STUDI DI CAGLIARI
Italy
EU contribution
€ 97 920
Address
Via Universita 40
09124 Cagliari
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Luca Saba (Dr.)
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 101 032
Address
Piazzale Aldo Moro 5
00185 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marco Francone (Prof.)
PAULA STRADINA KLINISKA UNIVERSITATES SLIMNICA
Latvia
EU contribution
€ 256 024
Address
Pilsonu Iela 13
1002 Riga
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrejs Erglis (Prof.)
LIETUVOS SVEIKATOS MOKSLU UNIVERSITETAS
Lithuania
EU contribution
€ 106 960
Address
A Mickeviciaus Gatve 9
44307 Kaunas
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mateleviciute Laima (Ms.)
WOJEWODZKI SZPITAL SPECJALISTYCZNY WE WROCLAWIU
Poland
EU contribution
€ 76 172
Address
Ul. Henryka Michala Kamienskiego 73 A
51 124 Wroclaw
Activity type
Research Organisations
Administrative Contact
Patrycja Gawora (Ms.)
CENTRO HOSPITALAR DE VILA NOVA DE GAIA/ESPINHO EPE
Portugal
EU contribution
€ 113 280
Address
Rua Conceicao Fernandes S/n
4434 502 Vila Nova De Gaia
Activity type
Research Organisations
Administrative Contact
Nuno Bettencourt (Dr.)
CARDIO MED SRL
Romania
EU contribution
€ 97 005
Address
22 Decembrie 1989 Strada 76 Ap 1
540124 Targu Mures
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Teodora Benedek (Dr.)
INSTITUT ZA KARDIOVASKULARNE BOLESTI VOJVODINE
Serbia
EU contribution
€ 64 260
Address
Put Doktora Goldmana 4
21204 Sremska Kamenica
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ljiljana Pupic (Ms.)
INSTITUT CATALA DE LA SALUT
Spain
EU contribution
€ 147 340
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Joan X Comella (Dr.)
OSTERGOTLANDS LANS LANDSTING

Participation ended

Sweden
Address
Larsgatan 49B
581 91 Linkoping
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Eva Swahn (Prof.)
KANTONSSPITAL ST. GALLEN

Participation ended

Switzerland
Address
Rorschacherstrasse 95
9007 St. Gallen
Activity type
Research Organisations
Administrative Contact
Cornelia De Martin
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 91 000
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joe Galloway (Mr.)
AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 132 160
Address
Longmoor Lane
L9 7AL Liverpool
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Gershan Davis (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Participation ended

France
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Lyddie Laaland (Ms.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 151 000
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daan Katchaki (Mr.)
FUNDACION VASCA DE INNOVACION E INVESTIGACION SANITARIAS
Spain
EU contribution
€ 228 600
Address
Ronda De Azkue,1
48902 Barakaldo
Activity type
Research Organisations
Administrative Contact
Irune Vegas Martinez (Mrs.)
CESKE VYSOKE UCENI TECHNICKE V PRAZE

Participation ended

Czechia
EU contribution
€ 24 600
Address
Jugoslavskych Partyzanu 1580/3
160 00 Praha
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vladimir Rogalewicz (Prof.)
Universitätsklinikum Jena
Germany
EU contribution
€ 199 000
Address
Bachstraße 18
07743 Jena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stefanie Höhn (Mrs.)
VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA
Finland
EU contribution
€ 80 480
Address
Kiinamyllynkatu 4-8
20520 Turku
Activity type
Research Organisations
Administrative Contact
Juhani Knuuti (Prof.)
INSTYTUT KARDIOLOGII IM. PRYMASA TYSIACLECIA STEFANA KARDYNALA WYSZYNSKIEGO
Poland
EU contribution
€ 29 955
Address
Ul. Alpejska 42
04628 Warszawa
Activity type
Research Organisations
Administrative Contact
Aleksandra Pajor (Mrs.)
"UNIVERSITATEA DE MEDICINA, FARMACIE, STIINTE SI TEHNOLOGIE ""GEORGE EMIL PALADE"" DIN TARGU MURES"
Romania
EU contribution
€ 18 520
Address
Street Gheorghe Marinescu 38
540139 Targu Mures
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paraschiva Munteanu (Mrs.)
FACULTY OF MEDICINE, UNIVERSITY OF BELGRADE
Serbia
EU contribution
€ 38 960
Address
Dr Subotica, 8
11000 Belgrade
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Slavica Petricevic (Mrs.)
Servicio Vasco de Salud Osakidetza
Spain
EU contribution
€ 46 000
Address
Alava 45
01006 Vitoria-gasteiz
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Ainhoa Martin (Mrs.)
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
EU contribution
€ 113 000
Address
5 Rue Watt
75013 Paris
Activity type
Research Organisations
Administrative Contact
Alicja Szofer-Araya (Mrs.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 39 980
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tine Mathiesen (Mrs.)