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Advanced Materials for Cardiac Regeneration (AMCARE)

Objective

The Advanced Materials for Cardiac Regeneration (AMCARE) consortium aims to establish a translational research program to develop truly restorative therapies for acute myocardial infarction repair (MI) by optimising cardiac progenitor cell (CPC) therapy using smart biomaterials and advanced drug delivery, and coupling these therapeutics with minimally-invasive surgical devices. Two distinct biomaterial delivery systems for CPCs will be investigated in the AMCARE work programme including HA-based patches (CardioPatch) and HA-hydrogels (CardioGel). We also propose to develop two prototypes of new surgical devices [C-CathGel and SPREDS] that will ensure a minimally invasive delivery and fixation approach that is safe and effective for each therapeutic. The combinations of advanced material carriers and surgical devices will be assessed in a large animal model of acute-MI to best align our approach to clinical translation. The novel formulations and delivery methods will help post-MI patients in restoring cardiac function by targeting for repair the underlying myocardium damage, and could potentially decrease morbidity and mortality in the future. These goals will be achieved by integrating numerous areas of materials science and stem cell biology as well as leaders in the field of medical devices, biomaterials and cardiovascular regeneration. We thus aim to improve long-term healthcare of EU citizens by offering a revolutionary therapeutic modality for the treatment of acute-MI.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /engineering and technology/industrial biotechnology/biomaterials
  • /social sciences/sociology/demography/mortality

Call for proposal

FP7-NMP-2013-SME-7
See other projects for this call

Funding Scheme

CP-TP - Collaborative Project targeted to a special group (such as SMEs)

Coordinator

ROYAL COLLEGE OF SURGEONS IN IRELAND
Address
Saint Stephen's Green 123
2 Dublin
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 286 514

Participants (11)

CONTIPRO BIOTECH SRO

Participation ended

Czechia
EU contribution
€ 210 446,30
Address
Dolni Dobrouc 401
56102 Dolni Dobrouc
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
EU contribution
€ 803 806
Address
College Green
2 Dublin
Activity type
Higher or Secondary Education Establishments
CONTIPRO AS
Czechia
EU contribution
€ 246 433,70
Address
Dolni Dobrouc 401
561 02 Dolni Dobrouc
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INNOVA SRL
Italy
EU contribution
€ 398 927
Address
Via Cicerone, 66
00193 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ADJUCOR GMBH
Germany
EU contribution
€ 795 960
Address
Menzinger Strasse 163
80997 Munchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CELYAD
Belgium
EU contribution
€ 1 240 734
Address
Rue Edouard Belin 12
1435 Mont Saint Guibert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EXPLORA SRL
Italy
EU contribution
€ 744 400
Address
Via Giacomo Peroni 386
00131 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 733 429
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 107 831
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
BOSTON SCIENTIFIC IRELAND LIMITED

Participation ended

Ireland
Address
Ballybrit Business Park
Ballybrit Galway
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BOSTON SCIENTIFIC LIMITED
Ireland
EU contribution
€ 226 868
Address
Ballybrit Business Park
H91 Galway
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)