Objective MiRacle focuses on the development of a therapeutic formulation for the treatment of head and neck cancer. Head and neck cancer contributes to approximately 5% of all cancers in the Western world. Unfortunately the majority of H&N cancer patients present with advanced stages of disease. These patients frequently develop locoregional recurrences, distant metastasis and/or second primary tumors resulting in 5-years survival rates of less than 60% The development of novel anti-cancer agents to improve outcome is therefore urgently awaited. The goal of MiRacle is the advancement of a therapeutic tumor-killing miRNA formulation towards the clinic by combining two innovative technologies, i.e. therapeutic miRNA and head and neck tumor specific targeted drug delivery. Such a project requires (1) expertise in the therapeutic application of miRNA (InteRNA) and knowledge on the synthesis of biochemical active miRNA (Biospring), (2) knowledge of drug formulations to deliver the therapeutic miRNA into humans (IC) and understanding the synthesis of complex drug formulations (Polymun), plus (3) in-depth knowledge of the therapeutic indication, e.g. H&N cancer (VUmc) and skilfulness in toxicity tests that are required for RNA based drug registration (LPT). We believe that this project encompasses all parties that are required to successfully bring a tumor killing miRNA towards registration for first in human testing. Fields of science medical and health sciencesclinical medicineoncologyhead and neck cancernatural sciencesbiological sciencesgeneticsRNA Programme(s) FP7-SME - Specific Programme "Capacities": Research for the benefit of SMEs Topic(s) SME-2013-1 - Research for SMEs Call for proposal FP7-SME-2013 See other projects for this call Funding Scheme BSG-SME - Research for SMEs Coordinator STICHTING AMSTERDAM UMC EU contribution € 3 961,73 Address DE BOELELAAN 1117 1081 HV Amsterdam Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Yvonne Koppelman (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all QUIET THERAPEUTICS LTD Participation ended Israel EU contribution € 268 142,60 Address YAKHIN INDUSTRIAL PARK 78172 ASHKELON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ron Lahav (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOSPRING GESELLSCHAFT FUR BIOTECHNOLOGIE MBH Germany EU contribution € 182 241,75 Address ALT-FECHENHEIM 34 60386 FRANKFURT AM MAIN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jorg Hauf (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INTERNA TECHNOLOGIES BV Netherlands EU contribution € 542 678,25 Address JONKERBOSPLEIN 52 6534 AB Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jack Veuskens (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LPT LABORATORY OF PHARMACOLOGY AND TOXICOLOGY GMBH & CO KG Germany EU contribution € 7 500,00 Address REDDERWEG 8 21147 HAMBURG See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jost Leuschner (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data OCTOPLUS NV Participation ended Netherlands EU contribution € 9 248,00 Address ZERNIKEDREEF 12 2333 CL LEIDEN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anton Mat Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INNOVACENTRIC Belgium EU contribution € 152 689,40 Address ELF NOVEMBERLAAN 16 3500 HASSELT See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jack Veuskens (Dr.) Links Contact the organisation Opens in new window Total cost No data POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH Austria EU contribution € 2 000,00 Address DONAUSTRASSE 99 3400 Klosterneuburg See on map Region Ostösterreich Niederösterreich Wiener Umland/Nordteil Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Dietmar Kantiger Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING VU Netherlands EU contribution € 3 538,27 Address DE BOELELAAN 1105 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Michel Telkamp (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
