Project description Virtual Physiological Human Show the project objective Hide the project objective NoTremor aims to provide patient specific computational models of the coupled brain and neuromuscular systems that will be subsequently used to improve the quality of analysis, correlation (of novel and established indicators) and progression of Parkinson's disease. In particular, it aspires to establish the neglected link between brain modelling and neuromuscular systems that will result in a holistic representation of the physiology for PD patients. A significant breakthrough of NoTremor is that these models will not be used for abstract representation of the physiology or as a match between theory and clinical measurements. NoTremor will integrate computational models of the basal ganglia and brainstem into a unique multi-scale parametric computational model that can be subsequently simulated in the NoTremor simulation engine in a physics-based manner. NoTremor will revolutionize research in the pathophysiology of neurodegenerative movement disorders and provide a novel approach for their analysis founded on a solid computational modelling basis that links midbrain degenerations to motor behaviour. The computational models will be quantified and validated through test campaigns with a very large cohort of PD patients. The ultimate challenging use of the NoTremor virtual patient models will be from the one side clinical decision support and from the other side the investigation, virtual prototyping and modeling of the influence of dopamine levels testing of new drugs using virtual patient models. Fields of science medical and health sciencesbasic medicinephysiologynatural sciencesbiological sciencesneurobiologycomputational neurosciencemedical and health sciencesbasic medicineneurologyparkinson Programme(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Topic(s) ICT-2013.5.2 - Virtual Physiological Human Call for proposal FP7-ICT-2013-10 See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS Address Charilaou thermi road 6 km 57001 Thermi thessaloniki Greece See on map Region Βόρεια Ελλάδα Κεντρική Μακεδονία Θεσσαλονίκη Activity type Research Organisations Administrative Contact Dimitrios Tzovaras (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 703 629,00 Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all UCB PHARMA SA Belgium EU contribution € 178 390,00 Address Allee de la recherche 60 1070 Brussels / bruxelles See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Duncan McHale (Prof.) Links Contact the organisation Opens in new window Website Opens in new window PANEPISTIMIO PATRON Greece EU contribution € 472 592,00 Address University campus rio patras 265 04 Rio patras See on map Region Κεντρική Ελλάδα Δυτική Ελλάδα Αχαΐα Activity type Higher or Secondary Education Establishments Administrative Contact Konstantinos Moustakas (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA DEGLI STUDI DI TRENTO Italy EU contribution € 398 180,00 Address Via calepina 14 38122 Trento See on map Region Nord-Est Provincia Autonoma di Trento Trento Activity type Higher or Secondary Education Establishments Administrative Contact Mauro Da Lio (Prof.) Links Contact the organisation Opens in new window Website Opens in new window THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 529 946,00 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Gill Wells (Ms.) Links Contact the organisation Opens in new window Website Opens in new window PARKINSON'S DISEASE SOCIETY OF THEUNITED KINGDOM LBG United Kingdom EU contribution € 118 228,00 Address Vauxhall bridge raod 215 SW1V 1EJ London See on map Region London Inner London — West Westminster Activity type Other Administrative Contact Arthur Roach (Dr.) Links Contact the organisation Opens in new window THE UNIVERSITY OF SHEFFIELD United Kingdom EU contribution € 469 557,00 Address Firth court western bank S10 2TN Sheffield See on map Region Yorkshire and the Humber South Yorkshire Sheffield Activity type Higher or Secondary Education Establishments Administrative Contact Joanne Watson (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window
