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Bedside monitoring of infection based on exhaled breath

Objective

Molecular analysis of exhaled breath is a new frontier in medical testing with an enormous potential for monitoring respiratory disease.
Breath tests are non-invasive and require minimal patient effort. This makes them applicable in a wide range of settings varying from the
intensive care unit (ICU) to home. Respiratory infections are the primary cause of death in ICU. More than half of the patients in ICUs
worldwide suffer from infections, which lengthen their hospital stays and increase their mortality rate. Timely detection and treatment is
important and monitoring infection via breath analysis will have a major impact on healthcare. Electronic nose sensor technology is being
developed but there is a need for clinical validation. Also it is not always clear to which specific compounds these sensors are sensitive. In
this proposal the focus is on developing a sensor technique, where measurements are obtained and processed at the bedside. This
solution will be dedicated to the detection of infection from breath. A synergistic approach is proposed between sensor technology
development, clinical validation and complex data interpretation. Knowledge will be exchanged between an industrial partner (Philips, NL)
strongly involved in the healthcare and well-being markets, two academic partners (University of Manchester, UK, Academic Medical
Centre, NL) that have an impressive track record in breath analysis research in a clinical environment and a research institution (University of Twente, NL) that has promising potential on bedside gas sensor technology that can be tailored to compounds of interest. The inter-sectorial
knowledge transfers as defined in this proposal are key to the success of this ambitious goal. The project consists of 6 highly multidisciplinary
work packages, which involve sensor development, clinical measurements and validation studies and the development of
complex data analysis tools.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /engineering and technology/environmental engineering/energy and fuels/fossil energy/gas
  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/clinical medicine/critical care medicine
  • /natural sciences/computer and information sciences/data science/data analysis

Call for proposal

FP7-PEOPLE-2013-IAPP
See other projects for this call

Funding Scheme

MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP)
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Address
Meibergdreef 15
1105AZ Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 201 834,33
Administrative Contact
Rebecca Massonet (Ms.)

Participants (3)

PHILIPS ELECTRONICS NEDERLAND BV
Netherlands
EU contribution
€ 387 802,93
Address
High Tech Campus 52
5656 AG Eindhoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Veronika Kiss (Ms.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 244 978,80
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Claire Faichnie (Ms.)
UNIVERSITEIT TWENTE
Netherlands
EU contribution
€ 43 332,91
Address
Drienerlolaan 5
7522 NB Enschede
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ferdinand Damhuis (Mr.)