Objective Objectives of the joint exchange program “DINaMiT” is to develop state-of-the art remotely responsive magnetic/metal nanoparticle functionalized drug delivery carriers for dual optical and magnetic resonance imaging modalities, equip such probes with theranostic detection/delivery capabilities and apply them for in-vivo study of anticancer drugs. To implement ambitious goals of such a program seven work-packages will be pursued. Each work-package will constitute of a necessary step for reaching the milestones and overall goals of the exchange programme.Functionalization of delivery carriers by nanoparticles is an important issue of successfully achieving the goals of the project. Optical imaging is the technique of choice for working with cell cultures and for routine fluorescent sample characterization. A significant advancement of the scientific research program is addition of magnetic response capabilities for such carriers, which results into dual optical / magnetically responsive system. Functionalized by nanoparticles, delivery carriers can be remotely activated based on the localized heating, which induces the permeability change of the carriers, but which does not affect the surrounding tissue. We envision using two-photon microscopy for deeper in-tissue reach. Magnetic functionality is viewed as a complementary approach which will allow even deeper reach. Magnetic resonance imaging (MRI) is a technique widely used for in-vivo diagnostic and tracking investigation.Polymeric and natural (red blood cells) delivery vehicles will be used for assembling ther-anostic carriers. Theranostic functionalities will be introduced by assembling the so-called multicompartment structures. Indeed, after such carriers are assembled and imaging/activation system is developed, in-vitro as well as in-vivo applications of such a system will be pursued. For in-vitro applications cell culture tests will be used, while that will be transferred for real in-vivo applications. Fields of science natural sciencesphysical sciencesopticsmicroscopymedical and health sciencesclinical medicineoncologyengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imagingengineering and technologynanotechnologynano-materials Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-IRSES - Marie Curie Action "International Research Staff Exchange Scheme" Call for proposal FP7-PEOPLE-2013-IRSES See other projects for this call Funding Scheme MC-IRSES - International research staff exchange scheme (IRSES) Coordinator CHARITE - UNIVERSITAETSMEDIZIN BERLIN EU contribution € 140 300,00 Address Chariteplatz 1 10117 Berlin Germany See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Mara-Theresa Klein (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITEIT GENT Belgium EU contribution € 43 800,00 Address SINT PIETERSNIEUWSTRAAT 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Administrative Contact Evelien Vandevelde (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO Italy EU contribution € 36 800,00 Address DUOMO 6 13100 Vercelli See on map Region Nord-Ovest Piemonte Vercelli Activity type Higher or Secondary Education Establishments Administrative Contact Ciro Isidoro (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI TORINO Italy EU contribution € 44 400,00 Address VIA GIUSEPPE VERDI 8 10124 Torino See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Administrative Contact Enzo Terreno (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data