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Programming synthetic networks for bio-based production of value chemicals

Objective

The global chemical industry is transitioning from petrochemical production processes to bio-based production processes. This transition creates a clear market need for technologies that reduce the development time and cost of cell factories. PROMYS will develop, validate and implement a novel synthetic biology platform technology termed ligand responsive regulation and selection systems. Ligand responsive regulation and selection systems are biological devices that integrate biological sensing modules, within larger regulatory networks to control cellular programs. This technology will drastically accelerate the construction, optimization and performance of cell factories by enabling industrial users to impose non-natural objectives on the engineered cell factory. PROMYS will address three major challenges in metabolic engineering that limit the development of new cell factories:
1) Synthetic pathway construction
2) Cell factory optimization
3) Control of populations during fermentation

Ligand responsive regulation and selection systems will directly couple the presence of a desired chemical product or flux state within a cell, to the survival of the cell. As such, they allow the in vivo identification of the needle (e.g. functional pathway or optimized cell factories) in a haystack (e.g. large libraries). In addition, the technology developed in PROMYS will be applied to deliver increased fermentation yields by continuously selecting for high yielding cell factories within the fermentation population.
PROMYS is industry driven and designed such that the expected innovations of each work package have a direct commercialization partner, which is willing to commit the necessary resources to develop commercial products from the innovation.

Field of science

  • /natural sciences/biological sciences/synthetic biology
  • /engineering and technology/industrial biotechnology/bioprocessing technologies/fermentation
  • /social sciences/economics and business/economics/production economics
  • /engineering and technology/industrial biotechnology/metabolic engineering

Call for proposal

FP7-KBBE-2013-7-single-stage
See other projects for this call

Funding Scheme

CP-TP - Collaborative Project targeted to a special group (such as SMEs)

Coordinator

DANMARKS TEKNISKE UNIVERSITET
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 312 890
Administrative Contact
Birte Rasmussen

Participants (6)

BACMINE SL
Spain
EU contribution
€ 813 471
Address
Calle Isaac Newton 2 Parque
28760 Tres Cantos
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pablo Pomposiello Miravent (Dr.)
TECHNISCHE UNIVERSITAT DARMSTADT
Germany
EU contribution
€ 904 418
Address
Karolinenplatz 5
64289 Darmstadt
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Melanie Meermann-Zimmermann (Dr.)
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 1 004 400
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dick Veldhuis (Dr.)
THE UNIVERSITY OF WARWICK
United Kingdom
EU contribution
€ 722 423
Address
Kirby Corner Road - University House
CV4 8UW Coventry
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Hedges (Dr.)
EVOLVA AG
Switzerland
EU contribution
€ 712 800
Address
Duggingerstrasse 23
4153 Reinach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Naesby (Mr.)
BIOSYNTIA APS
Denmark
EU contribution
€ 718 000
Address
Kogle Alle 6
2970 Horsholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andreas Laustsen (Mr.)