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Programming synthetic networks for bio-based production of value chemicals

Obiettivo

The global chemical industry is transitioning from petrochemical production processes to bio-based production processes. This transition creates a clear market need for technologies that reduce the development time and cost of cell factories. PROMYS will develop, validate and implement a novel synthetic biology platform technology termed ligand responsive regulation and selection systems. Ligand responsive regulation and selection systems are biological devices that integrate biological sensing modules, within larger regulatory networks to control cellular programs. This technology will drastically accelerate the construction, optimization and performance of cell factories by enabling industrial users to impose non-natural objectives on the engineered cell factory. PROMYS will address three major challenges in metabolic engineering that limit the development of new cell factories:
1) Synthetic pathway construction
2) Cell factory optimization
3) Control of populations during fermentation

Ligand responsive regulation and selection systems will directly couple the presence of a desired chemical product or flux state within a cell, to the survival of the cell. As such, they allow the in vivo identification of the needle (e.g. functional pathway or optimized cell factories) in a haystack (e.g. large libraries). In addition, the technology developed in PROMYS will be applied to deliver increased fermentation yields by continuously selecting for high yielding cell factories within the fermentation population.
PROMYS is industry driven and designed such that the expected innovations of each work package have a direct commercialization partner, which is willing to commit the necessary resources to develop commercial products from the innovation.

Invito a presentare proposte

FP7-KBBE-2013-7-single-stage
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Coordinatore

DANMARKS TEKNISKE UNIVERSITET
Indirizzo
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Danimarca

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Birte Rasmussen
Contributo UE
€ 2 312 890

Partecipanti (6)

BACMINE SL
Spagna
Contributo UE
€ 813 471
Indirizzo
Calle Isaac Newton 2 Parque
28760 Tres Cantos

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Pablo Pomposiello Miravent (Dr.)
TECHNISCHE UNIVERSITAT DARMSTADT
Germania
Contributo UE
€ 904 418
Indirizzo
Karolinenplatz 5
64289 Darmstadt

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Melanie Meermann-Zimmermann (Dr.)
RIJKSUNIVERSITEIT GRONINGEN
Paesi Bassi
Contributo UE
€ 1 004 400
Indirizzo
Broerstraat 5
9712CP Groningen

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Dick Veldhuis (Dr.)
THE UNIVERSITY OF WARWICK
United Kingdom
Contributo UE
€ 722 423
Indirizzo
Kirby Corner Road - University House
CV4 8UW Coventry

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Peter Hedges (Dr.)
EVOLVA AG
Svizzera
Contributo UE
€ 712 800
Indirizzo
Duggingerstrasse 23
4153 Reinach

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Michael Naesby (Mr.)
BIOSYNTIA APS
Danimarca
Contributo UE
€ 718 000
Indirizzo
Kogle Alle 6
2970 Horsholm

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Andreas Laustsen (Mr.)