Objective "Pneumonia is leading cause of death from infection. During infection, microbial presence is monitored by receptors recognizing evolutionary conserved structures. Pathogen recognition is associated with the activation of few regulators and signaling pathways controlling host defence systems. A better understanding of the host-pathogen interaction offers the potential for pharmacological intervention by targeting the host side.U-KARE aims to gain a holistic understanding of the networks conveying the cross-talk beteen the human pathogen Klebsiella pneumoniae (KP) and the innate immune system. KP is one of the most frequent antibiotic-resistant bacteria isolated in hospitals and the community. KP represents a paradigm of an emerging pathogen, and therefore it is both urgent and necesary to better understand its pathophysiology. My laboratory has demosntrated that KP subverts the activation of host defence processes (receptor-mediated KP recognition, and NF-kB activation) to survive in the lung. These findings lead us to hypothesize that ""the capacity of KP to survive in the lung correlates with the pathogen ability to modulate innate immune responses in its own benefit"".Critical questions that will pursued are: (i) which are KP strategies to take control over host post-transcriptional modifications; (ii) how does KP manipulate IFN-dependent pathways; (iii) how does KP manipulate cell death pathways; (iv) how does KP avoid autophagy; and (v) how does the host affect KP transcriptome.By a multidisciplinary approach encompassing microbiology, cell biology, functional genomics and immunology, U-KARE will expand our current understanding of the strategies used by KP to survive in the lung. On top of this, U-KARE will explore some of the most novel and fundamental topics in the infection biology which could lead to the identification of novel therapies based on modulating the host-pathogen interaction." Fields of science medical and health sciencesclinical medicinepneumologynatural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicinephysiologypathophysiologynatural sciencesbiological sciencescell biologymedical and health sciencesbasic medicineimmunology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-CIG - Marie-Curie Action: "Career Integration Grants" Call for proposal FP7-PEOPLE-2013-CIG See other projects for this call Funding Scheme MC-CIG - Support for training and career development of researcher (CIG) Coordinator THE QUEEN'S UNIVERSITY OF BELFAST EU contribution € 100 000,00 Address UNIVERSITY ROAD LANYON BUILDING BT7 1NN Belfast United Kingdom See on map Region Northern Ireland Northern Ireland Belfast Activity type Higher or Secondary Education Establishments Administrative Contact Colleen Spence (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
