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Organocatalytic synthesis of fluorine compounds. Development of new methodologies for the enantioselective introduction of fluorine building blocks via CH activation of sp3 carbon

Objective

"The Project will deal with the activation of inert Csp3-H bonds and the enantioselective addition of fluorocarbon nucleophiles to lead to the enantioselective synthesis of fluorinated compounds. The impact of the research will be highly significant to several areas. First of all, a general method for a green and enantioselective synthesis of fluorine compounds through Csp3-H activation will represent a ground-breaking advance in the field and will interest organic chemists in general from both academic and industrial backgrounds. The development of new a green procedure that avoid the use of metals, and diminishes the generation of waste will have an important impact to chemical industry. Moreover the possibility to add a fluorine block in later stages synthesis through Csp3-H activation will be an important tool in the hit to led process in pharmaceutical industry, due the possibility to enhance the metabolic properties of active compounds by simply adding a fluorine residue."

Field of science

  • /natural sciences/chemical sciences/inorganic chemistry/metals

Call for proposal

FP7-PEOPLE-2013-CIG
See other projects for this call

Funding Scheme

MC-CIG - Support for training and career development of researcher (CIG)

Coordinator

UNIVERSITY OF SOUTHAMPTON
Address
Highfield
SO17 1BJ Southampton
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 100 000
Administrative Contact
Yan Qiao (Ms.)