Objective
Heart failure is a major health issue and a cause of death and disability. The endogenous regenerative capacity of the heart is too weak to recover from damage and instead the heart repairs damage by synthesis of a scar tissue leading to functional deterioration. To improve cardiac regeneration, stem cell therapies and material-based approaches have been developed but up till now with limited success as we still lack detailed knowledge of and the functional technology to guide the regenerative process. Cardiac tissue is composed of muscle cells, non-muscle cells and extracellular matrix organized into a complex 3-dimensional architecture. The regeneration process requires specialization of cardiac stem cells in combination with remodelling of the extracellular matrix to form a functional contractile tissue. The Notch signalling pathway is a unique therapeutic target for regeneration of the heart, but we no nothing about the crosstalk between Notch and the biomechanical microenvironment. We aim to develop an in vitro model system using in situ differentiation of cardiac stem cells on 3-dimensional microtissue. The tissue can be engineered to mimic healthy or diseased myocardium tissue and be mechanically stimulated to mimic the beating heart. Using the model we aim to gain in-depth understanding on how the extracellular matrix and changes therein and the Notch signalling pathway, are interlinked. To use Notch modulation as a handle in cardiac regeneration we will develop technology for temporally and spatially controlled modulation of Notch signalling and build a prototype of functional scaffold for cardiac stem cell differentiation comprised of controlled delivery of Notch modulators from a synthetic matrix.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine cardiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.