Final Report Summary - GBMTARGET (Targeting Glioblastoma Signalling)
We have demonstrated that CATH-FunFams are the druggable entities within protein targets and developed a scheme to associate drugs to protein domains. We have modelled the signalling in gliomas as a network, to identify potential targets, and we proposed drugs active on them based on our drug-domain associations.
Our computational platform is easily extensible to other cancer types and even other diseases, enabling an efficient and cost-effective strategy for the identification of pharmacological targets and the repurposing of drugs.