Objective
With 2,6 million new cases and 1,26 million deaths in 2012, cancer is the most important cause of death in the European Union (EU). The most common cancer forms are breast cancer, prostate cancer, bowel cancer and lung cancer. The Hedgehog pathway is one of the most important signalling pathways in tumourigenic processes and known to be involved in all of these four types of tumours that represent 52% of all cancer cases in the EU. Thereby, the key mediator of the signalling pathway in mammals is the protein Sonic Hedgehog (Shh). During its maturation, the morphogen Shh is post-translationally modified in the endoplasmic reticulum (e.g. autocatalytically cleaved and lipidated) and transported to the cell membrane. The subsequent release of the signalling fragment into the surrounding area of the expressing cell results in the formation of Shh multimers that are able to induce genes involved in the development of target cells. Due to its emerging impact on cancer development, several therapeutic approaches target the Shh pathway. Currently there are numerous ongoing clinical trials of corresponding drugs. In the context of the development of new cancer diagnostic and treatment approaches, it is of vital importance to fully understand the mechanisms of signalling pathways involved in the tumourigenic process in order to design effective therapies. However, crucial aspects of the Sonic Hedgehog pathway, particularly the mechanism of release of the Shh singalling complex from the expressing cell, remain to be elucidated, due to a lack of tools to investigate this multiply chemically modified protein complex. The aim of this project is to investigate the mechanism for release of Shh and the formation of well-defined active Shh multimers through a combination of organic synthesis with proteomics and cell biology to elucidate this essential process in molecular detail for the first time. This highly multidisciplinary approach lies at the cutting edge of chemical biology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine oncology prostate cancer
- medical and health sciences clinical medicine oncology lung cancer
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine oncology breast cancer
- medical and health sciences clinical medicine oncology colorectal cancer
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW7 2AZ LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.