Objective
Abnormal vascular network formation is a prerequisite for tumor growth. This phenomenon has prompted the development of therapeutic approaches targeting molecules involved in the formation of pathological blood vessels such as VEGF and its receptors VEGFR1, VEGFR2 and VEGFR3. Although some patients benefited from such an approach, the majority of patients had a poor outcome through a transient decrease of the tumor/metastases accompanied by the selection of more aggressive tumors cells.
Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, responsible for approximately 80% of cases. It has been described as being among the most lethal of all the urological cancers. One major problem encountered in cancer patients, including RCC patients treated with anti-angiogenesis drugs, is the recurrence of metastases and even the development of new metastatic niches. Therefore, we postulate that the over-expression of VEGF-C, a growth factor for vascular and lymphatic endothelial cells, is responsible for tumor cells metastasis in response to anti-angiogenesis therapy.
Hence, the objective of our project is to determine the molecular mechanisms leading to the expression of VEGF-C after treatment with anti-angiogenesis drugs. Because VEGF-C may constitute both a predictive marker and a new pertinent therapeutic target, its role in acquired metastatic properties of RCC following anti-angiogenesis treatments deserves to be rigorously investigated. We will focus on the transcriptional regulation of VEGF-C and the stability of its mRNA. These goals will be achieved through the use of relevant cellular and animal models.
Since the anti-angiogenesis therapies lead to genetic adaptation of tumor cells, probably due to expression of receptors targeted by anti-angiogenesis drugs, our ultimate goal is to identify important partners that play a key role in the escape to anti-angiogenesis therapies that should have been curative.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.