Objective
Tissues in the human body are exposed to cyclic loading and have the capacity to adapt, to meet new loading demands. Cells facilitate such adaptation by responding to mechanical triggers, which depends on the balance between endogenous tension (cellular forces) and exogenous tension (matrix stiffness and resistance to stretch). This is regulated by matrix adhesions: the cellular force sensors. In healthy tissue, cells can positively contribute to tissue functioning by synthesizing additional matrix components, a process initiated at matrix adhesions, the connection between cells and matrix. However, in various fibrous tissue pathologies (e.g. atherosclerosis, cardiomyopathy, tendon overload), a progressive increase in matrix disorganization is observed. In search of the underlying cause of this matrix disorganization, this proposal aims to determine how mechanoresponsive matrix adhesion proteins react to mechanical perturbations and impact matrix remodeling in healthy and diseased tissue. In a multidisciplinary approach, novel 3D model systems will be used to engineer micro-tissues subjected to mechanical perturbations. Real-time imaging will expose matrix adhesion functioning upon imbalance between endogenous and exogenous tension. The response of mechanosensitive matrix adhesion proteins in healthy and diseased tissues will be quantified upon cyclic stretching, and its impact on matrix remodeling. These results will unravel the underlying cause for tissue remodeling associated with fibrous tissue pathology, to ultimately provide a treatment strategy. The proposal aims at bridging the classical 2D cell research and in vivo studies. Both lack the possibility to study cellular processes at the molecular, cell and tissue level in a native-like environment, whereby tissues are exposed to physiologically relevant mechanical and biochemical loading. Bridging this gap by adopting this genuinely new approach will therefore boost European excellence and competitiveness.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- natural sciences biological sciences biochemistry biomolecules proteins
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.