Final Report Summary - TOXKINBIO (Toxicokinetics and biotransformation in aquatic invertebrates) Overall the project the developed an integrated experimental-modelling strategy for the study of toxicokinetics and biotransformation patterns across different species enabling ultimately a more comprehensive and quantitative prediction of the effects of chemicals on ecosystems health. In particular, the project built this strategy upon a matrix of three aquatic invertebrate model species by four selected chemicals relevant to freshwater systems and compared biotransformation pathways and other toxicokinetic processes twelve chemical-organism combinations for models parameterisation. This work improved our understanding of hwat happens to pharmaceuticals in the environment. We learned about how different freshwater species (a snail, a shrimp and water flea) take up pharmaceuticals, metabolise and transfrom them and then excrete them. The main finding is that there are surprisingly big differences between the species. Also we found that some pharmaceuticals are metabolised a lot and others much less so. This helps to assess the risks of pharmaceuticals in the environment and can inform design of environmentally friendly drugs. Thus it is of interest to industry and policy makers.
