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Content archived on 2024-06-18

Neural coding of fear memories formation and extinction in frontal association network

Objective

"The neocortex is the brain area that is most expanded in the human brain. It is thought that neocortical function underlies the remarkable adaptive and associative learning skills of mammals. Learning-dependent neocortical plasticity is supposed to rely on subtle changes in the spatial pattern and level of neuronal activity that likely depend on connectivity rearrangement through synapses turnover and/or activity-dependent strengthening and weakening of pre-established synapses. However, whether this structural-functional cascade occurs in higher cognitive frontal areas during associative stimulus learning is currently not known. By combining in vivo two-photon long-term structural imaging of dendritic spines, large-scale neuronal calcium imaging, and whole-cell recording in the behaving animal, we aim at understanding how the formation and extinction of associative fear memories are implemented by neuronal circuits in rodent frontal association cortex (FrA). Understanding of how different neurons in higher cortical areas modulate the structure of their connections in response to learning, and how this would alter the cortical processing is a key to understand how we store information and acquire new skills, and potentially help to advance the design of new strategies toward memory enhancement and neuronal repair in a wide range of brain diseases."

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2013-CIG
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-CIG - Support for training and career development of researcher (CIG)

Coordinator

UNIVERSITE DE BORDEAUX
EU contribution
€ 100 000,00
Address
PLACE PEY BERLAND 35
33000 BORDEAUX
France

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Region
Nouvelle-Aquitaine Aquitaine Gironde
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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