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Aging Lungs in European Cohorts

Objectif

This programme of work will advance the understanding of the combined effects of factors that cause poor lung function, respiratory disability and the development of COPD . This will be achieved by examination of determinants of lung growth and lung function decline within existing cohorts that cover the whole life course, and which have followed, in detail, the respiratory health status of over 25000 European children and adults from the early 1990’s to the present day. Following a comprehensive programme of risk factor identification we will generate a predictive risk score. The programme includes 1) identification of behavioural, environmental, occupational, nutritional, other modifiable lifestyle, genetic determinant of poor lung growth, excess lung function decline and occurrence of low lung function, respiratory disability and COPD within existing child and adult cohorts 2) generation of new data to fill gaps in knowledge on pre-conception and transgenerational determinants and risk factors 3) validation of the role of risk factors by integration of data from relevant disciplines, integration of data from the cohort-related population-based biobanks and exploitation of appropriate statistical techniques 4) generation of information on change in DNA methylation patterns to identify epigenetic changes associated with both disease development and exposure to specific risk factors 5) generation of a predictive risk score for individual risk stratification that takes account of the combined effects of factors that cause poor lung growth, lung function decline, respiratory disability, and COPD and 6) implementation of an online interactive tool for personalised risk prediction based which will be disseminated freely and widely to the population, patients and health care providers. The work will provide an evidence base for risk identification at individual and population level that can underpin future preventive and therapeutic strategies and policies.

Appel à propositions

H2020-PHC-2014-two-stage
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Coordinateur

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Adresse
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom

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Type d’activité
Higher or Secondary Education Establishments
Contribution de l’UE
€ 2 567 232

Participants (10)

UNIVERSITY OF BRISTOL
United Kingdom
Contribution de l’UE
€ 401 243,75
Adresse
Beacon House Queens Road
BS8 1QU Bristol

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Type d’activité
Higher or Secondary Education Establishments
FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Espagne
Contribution de l’UE
€ 496 026
Adresse
C Rossello 132 Planta 05
08036 Barcelona

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Type d’activité
Research Organisations
UNIVERSITETET I BERGEN
Norvège
Contribution de l’UE
€ 550 000
Adresse
Museplassen 1
5020 Bergen

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Type d’activité
Higher or Secondary Education Establishments
UNIVERSITY OF SOUTHAMPTON
United Kingdom
Contribution de l’UE
€ 394 712,50
Adresse
Highfield
SO17 1BJ Southampton

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Type d’activité
Higher or Secondary Education Establishments
SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT
Suisse
Contribution de l’UE
€ 0
Adresse
Kreuzstrasse 2
4123 Allschwil

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Type d’activité
Research Organisations
UNIVERSITA DEGLI STUDI DI VERONA
Italie
Contribution de l’UE
€ 405 000
Adresse
Via Dell Artigliere 8
37129 Verona

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Type d’activité
Higher or Secondary Education Establishments
LANDSPITALI UNIVERSITY HOSPITAL
Islande
Contribution de l’UE
€ 125 000
Adresse
Eiriksgata 5
101 Reykjavik

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Type d’activité
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Contribution de l’UE
€ 215 880
Adresse
Rue De Tolbiac 101
75654 Paris

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Type d’activité
Research Organisations
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Allemagne
Contribution de l’UE
€ 379 000
Adresse
Geschwister Scholl Platz 1
80539 Muenchen

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Type d’activité
Higher or Secondary Education Establishments
UNIVERSITY OF MELBOURNE
Australie
Contribution de l’UE
€ 0
Adresse
Parkvilleoffice Of The Vice Chancellor
3010 Melbourne

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Type d’activité
Higher or Secondary Education Establishments