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DOLORisk: Understanding risk factors and determinants for neuropathic pain


Submission package clinical study 5

mandatory deliverable, submission package clinical study 5

Submission package clinical study 7

Mandatory deliverable. Submission package clinical study 7

Submission package clinical study 6

Mandatory deliverable, submission package clinical study 6

Submission package clinical study 4

mandatory deliverable, submission package clinical study 4

All approvals package clinical study 2

All approvals package clinical study 2

Generation of a protein interaction network using transcriptional profiling and pain risk associated gene outcommes

To use data from transcriptional profiling and gene association to enhance the painnetworks database which will be publicly available in web based format and enable visualisation of protein interactions of pain associated genes.

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Systematic review and meta-analysis of genetic risk factors for neuropathic pain

Author(s): Abirami Veluchamy, Harry L. Hébert, Weihua Meng, Colin N.A. Palmer, Blair H. Smith
Published in: PAIN, Issue 159/5, 2018, Page(s) 825-848, ISSN 0304-3959
DOI: 10.1097/j.pain.0000000000001164

Rare Nav1.7 variants associated with painful diabetic peripheral neuropathy

Author(s): Iulia Blesneac, Andreas C. Themistocleous, Carl Fratter, Linus J. Conrad, Juan D. Ramirez, James J. Cox, Solomon Tesfaye, Pallai R. Shillo, Andrew S.C. Rice, Stephen J. Tucker, David L.H. Bennett
Published in: PAIN, 2018, Page(s) 1, ISSN 0304-3959
DOI: 10.1097/j.pain.0000000000001116

Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS)

Author(s): Harry L Hébert, Bridget Shepherd, Keith Milburn, Abirami Veluchamy, Weihua Meng, Fiona Carr, Louise A Donnelly, Roger Tavendale, Graham Leese, Helen M Colhoun, Ellie Dow, Andrew D Morris, Alexander S Doney, Chim C Lang, Ewan R Pearson, Blair H Smith, Colin N A Palmer
Published in: International Journal of Epidemiology, Issue 47/2, 2017, Page(s) 380-381j, ISSN 0300-5771
DOI: 10.1093/ije/dyx140

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

Author(s): Natalie R. van Zuydam, Emma Ahlqvist, Niina Sandholm, Harshal Deshmukh, N. William Rayner, Moustafa Abdalla, Claes Ladenvall, Daniel Ziemek, Eric Fauman, Neil R. Robertson, Paul M. McKeigue, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Annalisa Perna, Erica Rurali, M. Loredana Marcovecchio, Robert P. Igo, Rany M. Salem, Norberto Perico, Maria Lajer, Annemari Käräjämäki, Minako Imamura, Michia
Published in: Diabetes, Issue 67/7, 2018, Page(s) 1414-1427, ISSN 0012-1797
DOI: 10.2337/db17-0914

Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients

Author(s): Christine B. Sieberg, Caitlin Taras, Aya Gomaa, Chelsea Nickerson, Cindy Wong, Catherine Ward, Georgios Baskozos, David L.H. Bennett, Juan D. Ramirez, Andreas C. Themistocleous, Andrew S.C. Rice, Pallai R. Shillo, Solomon Tesfaye, Robert R. Edwards, Nick A. Andrews, Charles Berde, Michael Costigan
Published in: PAIN Reports, Issue 3/3, 2018, Page(s) e651, ISSN 2471-2531
DOI: 10.1097/PR9.0000000000000651

A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N = 223,773)

Author(s): Weihua Meng, Mark J. Adams, Harry L. Hebert, Ian J. Deary, Andrew M. McIntosh, Blair H. Smith
Published in: EBioMedicine, Issue 28, 2018, Page(s) 180-186, ISSN 2352-3964
DOI: 10.1016/j.ebiom.2018.01.023

A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy

Author(s): Andrew R Segerdahl, Andreas C Themistocleous, Dean Fido, David L Bennett, Irene Tracey
Published in: Brain, Issue 141/2, 2018, Page(s) 357-364, ISSN 0006-8950
DOI: 10.1093/brain/awx337

Using stratified medicine to understand, diagnose, and treat neuropathic pain

Author(s): Andreas C. Themistocleous, Geert Crombez, Georgios Baskozos, David L. Bennett
Published in: PAIN, Issue 159, 2018, Page(s) S31-S42, ISSN 0304-3959
DOI: 10.1097/j.pain.0000000000001301

The novel activity of carbamazepine as an activation modulator extends from NaV1.7 mutations to the NaV1.8-S242T mutant channel from a patient with painful diabetic neuropathy

Author(s): Chongyang Han, Andreas C Themistocleous, Mark Estacion, Fadia B Dib-Hajj, Iulia Blesneac, Lawrence Macala, Carl Fratter, David L Bennett, Stephen G. Waxman, Sulayman D. Dib-Hajj
Published in: Molecular Pharmacology, 2018, Page(s) mol.118.113076, ISSN 0026-895X
DOI: 10.1124/mol.118.113076

DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain

Author(s): Mathilde M.V. Pascal, Andreas C. Themistocleous, Ralf Baron, Andreas Binder, Didier Bouhassira, Geert Crombez, Nanna B. Finnerup, Janne Gierthmühlen, Yelena Granovsky, Leif Groop, Harry L. Hebert, Troels S. Jensen, Kristinn Johnsen, Mark I. McCarthy, Weihua Meng, Colin N.A. Palmer, Andrew S.C. Rice, Jordi Serra, Romà Solà, David Yarnitsky, Blair H. Smith, Nadine Attal, David L.H. Bennett
Published in: Wellcome Open Research, Issue 3, 2018, Page(s) 63, ISSN 2398-502X
DOI: 10.12688/wellcomeopenres.14576.1

The Pain in Neuropathy Study (PiNS)

Author(s): Andreas C. Themistocleous, Juan D. Ramirez, Pallai R. Shillo, Jonathan G. Lees, Dinesh Selvarajah, Christine Orengo, Solomon Tesfaye, Andrew S.C. Rice, David L.H. Bennett
Published in: PAIN, Issue 157/5, 2016, Page(s) 1132-1145, ISSN 0304-3959
DOI: 10.1097/j.pain.0000000000000491

Neuropathic pain

Author(s): Nanna B. Finnerup, Simon Haroutounian, Peter Kamerman, Ralf Baron, David L.H. Bennett, Didier Bouhassira, Giorgio Cruccu, Roy Freeman, Per Hansson, Turo Nurmikko, Srinivasa N. Raja, Andrew S.C. Rice, Jordi Serra, Blair H. Smith, Rolf-Detlef Treede, Troels S. Jensen
Published in: PAIN, Issue 157/8, 2016, Page(s) 1599-1606, ISSN 0304-3959
DOI: 10.1097/j.pain.0000000000000492

Risk factors for neuropathic pain in diabetes mellitus

Author(s): Harry L. Hébert, Abirami Veluchamy, Nicola Torrance, Blair H. Smith
Published in: PAIN, Issue 158/4, 2017, Page(s) 1, ISSN 0304-3959
DOI: 10.1097/j.pain.0000000000000785

Reliability of conditioned pain modulation

Author(s): Donna L. Kennedy, Harriet I. Kemp, Deborah Ridout, David Yarnitsky, Andrew S.C. Rice
Published in: PAIN, Issue 157/11, 2016, Page(s) 2410-2419, ISSN 0304-3959
DOI: 10.1097/j.pain.0000000000000689

Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies

Author(s): Oliver van Hecke, Peter R. Kamerman, Nadine Attal, Ralf Baron, Gyda Bjornsdottir, David L.H. Bennett, Michael I. Bennett, Didier Bouhassira, Luda Diatchenko, Roy Freeman, Rainer Freynhagen, Maija Haanpää, Troels S. Jensen, Srinivasa N. Raja, Andrew S.C. Rice, Zeʼev Seltzer, Thorgeir E. Thorgeirsson, David Yarnitsky, Blair H. Smith
Published in: PAIN, Issue 156/11, 2015, Page(s) 2337-2353, ISSN 0304-3959
DOI: 10.1097/j.pain.0000000000000335

Trigeminal neuralgia

Author(s): Giorgio Cruccu, Nanna B. Finnerup, Troels S. Jensen, Joachim Scholz, Marc Sindou, Peter Svensson, Rolf-Detlef Treede, Joanna M. Zakrzewska, Turo Nurmikko
Published in: Neurology, Issue 87/2, 2016, Page(s) 220-228, ISSN 0028-3878
DOI: 10.1212/WNL.0000000000002840

Peripheral neuropathic pain

Author(s): Ralf Baron, Christoph Maier, Nadine Attal, Andreas Binder, Didier Bouhassira, Giorgio Cruccu, Nanna B. Finnerup, Maija Haanpää, Per Hansson, Philipp Hüllemann, Troels S. Jensen, Rainer Freynhagen, Jeffrey D. Kennedy, Walter Magerl, Tina Mainka, Maren Reimer, Andrew S.C. Rice, Märta Segerdahl, Jordi Serra, Sören Sindrup, Claudia Sommer, Thomas Tölle, Jan Vollert, Rolf-Detlef Treede
Published in: PAIN, Issue 158/2, 2017, Page(s) 261-272, ISSN 0304-3959
DOI: 10.1097/j.pain.0000000000000753

Neuropathic pain

Author(s): Luana Colloca, Taylor Ludman, Didier Bouhassira, Ralf Baron, Anthony H. Dickenson, David Yarnitsky, Roy Freeman, Andrea Truini, Nadine Attal, Nanna B. Finnerup, Christopher Eccleston, Eija Kalso, David L. Bennett, Robert H. Dworkin, Srinivasa N. Raja
Published in: Nature Reviews Disease Primers, Issue 3, 2017, Page(s) 17002, ISSN 2056-676X
DOI: 10.1038/nrdp.2017.2

Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury

Author(s): Georgios Baskozos, John M. Dawes, Jean S. Austin, Ana Antunes-Martins, Lucy McDermott, Alex J. Clark, Teodora Trendafilova, Jon G. Lees, Stephen B. McMahon, Jeffrey S. Mogil, Christine Orengo, David L. Bennett
Published in: PAIN, Issue 160/2, 2019, Page(s) 463-485, ISSN 0304-3959
DOI: 10.1097/j.pain.0000000000001416

Defining the Functional Role of NaV1.7 in Human Nociception

Author(s): Lucy A. McDermott, Greg A. Weir, Andreas C. Themistocleous, Andrew R. Segerdahl, Iulia Blesneac, Georgios Baskozos, Alex J. Clark, Val Millar, Liam J. Peck, Daniel Ebner, Irene Tracey, Jordi Serra, David L. Bennett
Published in: Neuron, Issue 101/5, 2019, Page(s) 905-919.e8, ISSN 0896-6273
DOI: 10.1016/j.neuron.2019.01.047

The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes

Author(s): Astrid J Terkelsen, Páll Karlsson, Giuseppe Lauria, Roy Freeman, Nanna B Finnerup, Troels S Jensen
Published in: The Lancet Neurology, Issue 16/11, 2017, Page(s) 934-944, ISSN 1474-4422
DOI: 10.1016/s1474-4422(17)30329-0

New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain

Author(s): Eva L. Feldman, Klaus-Armin Nave, Troels S. Jensen, David L.H. Bennett
Published in: Neuron, Issue 93/6, 2017, Page(s) 1296-1313, ISSN 0896-6273
DOI: 10.1016/j.neuron.2017.02.005

Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source

Author(s): Greg A Weir, Steven J Middleton, Alex J Clark, Tarun Daniel, Nikita Khovanov, Stephen B McMahon, David L Bennett
Published in: Brain, Issue 140/10, 2017, Page(s) 2570-2585, ISSN 0006-8950
DOI: 10.1093/brain/awx201

Axonal excitability changes and acute symptoms of oxaliplatin treatment: In vivo evidence for slowed sodium channel inactivation

Author(s): Rikke Heide, Hugh Bostock, Lise Ventzel, Peter Grafe, Joseph Bergmans, Anders Fuglsang-Frederiksen, Nanna B. Finnerup, Hatice Tankisi
Published in: Clinical Neurophysiology, Issue 129/3, 2018, Page(s) 694-706, ISSN 1388-2457
DOI: 10.1016/j.clinph.2017.11.015

Germline selection shapes human mitochondrial DNA diversity

Author(s): Wei Wei, Salih Tuna, Michael J. Keogh, Katherine R. Smith, Timothy J. Aitman, Phil L. Beales, David L. Bennett, Daniel P. Gale, Maria A. K. Bitner-Glindzicz, Graeme C. Black, Paul Brennan, Perry Elliott, Frances A. Flinter, R. Andres Floto, Henry Houlden, Melita Irving, Ania Koziell, Eamonn R. Maher, Hugh S. Markus, Nicholas W. Morrell, William G. Newman, Irene Roberts, John A. Sayer, Kenneth G. C
Published in: Science, Issue 364/6442, 2019, Page(s) eaau6520, ISSN 0036-8075
DOI: 10.1126/science.aau6520

Genome-wide association study of knee pain identifies associations with GDF5 and COL27A1 in UK Biobank

Author(s): Weihua Meng, Mark J. Adams, Colin N. A. Palmer, Jingchunzi Shi, Adam Auton, Kathleen A. Ryan, Joanne M. Jordan, Braxton D. Mitchell, Rebecca D. Jackson, Michelle S. Yau, Andrew M. McIntosh, Blair H. Smith
Published in: Communications Biology, Issue 2/1, 2019, Page(s) 1-8, ISSN 2399-3642
DOI: 10.1038/s42003-019-0568-2

Multidimensional screening for predicting pain problems in adults

Author(s): Elke Veirman, Dimitri M. L. Van Ryckeghem, Annick De Paepe, Olivia J. Kirtley, Geert Crombez
Published in: PAIN Reports, Issue 4(2019), 2019, Page(s) 1, ISSN 2471-2531
DOI: 10.1097/pr9.0000000000000775

Stratifying patients with peripheral neuropathic pain based on sensory profiles

Author(s): Jan Vollert, Christoph Maier, Nadine Attal, David L.H. Bennett, Didier Bouhassira, Elena K. Enax-Krumova, Nanna B. Finnerup, Rainer Freynhagen, Janne Gierthmühlen, Maija Haanpää, Per Hansson, Philipp Hüllemann, Troels S. Jensen, Walter Magerl, Juan D. Ramirez, Andrew S.C. Rice, Sigrid Schuh-Hofer, Märta Segerdahl, Jordi Serra, Pallai R. Shillo, Soeren Sindrup, Solomon Tesfaye, Andreas C. Them
Published in: PAIN, Issue 158/8, 2017, Page(s) 1446-1455, ISSN 0304-3959
DOI: 10.1097/j.pain.0000000000000935