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Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging

Objective

The Gluco-Psychosocial Axis (GPA) concerns the interplay of factors determining glucose metabolism and insulin sensitivity and the neuroendocrine response resulting from exposure to psychosocial stress. A sub-optimal GPA influences the development of type 2 diabetes and related impairments with varying degrees of interplay between genetics and early growth (particularly adiposity and cognitive function), and social, occupational, and other modifiable lifestyle factors. Many exposures apply from throughout life, and potential exposure to a sub-optimal GPA lead to a cumulative risk of ill health and decreased economic prospects for the ageing. Understanding these factors, interactions and extent they contribute to the preservation of glucose homeostasis and psychosocial functioning is important for the development of preventive and therapeutic measures promoting healthy and active ageing. DynaHEALTH will contribute to implementing a dynamic model for early GPA risk identification and validation, allowing development of risk-based prevention tools and policies that will help to inform policy makers on the best periods to invest in cost-effective and sustainable healthcare strategies. DynaHEALTH comprises 13 partners from academic/private sectors and will leverage data from 21 birth cohorts and intervention studies, involving 1.5 million Europeans. By identifying biological and psychosocial determinants of the GPA and characterising metabolic and epigenetic factors, whilst quantifying the impact of exposure to an optimal lifelong GPA, DynaHEALTH will influence weight gain, glucose homeostasis, employability, health deterioration and disease accumulation as individuals age. DynaHEALTH includes the potential to exploit the results for new technologies and strategies, adding to our understanding of pathways related to healthy and active ageing, underpinning options for targeted, personalised healthcare and mitigating the effects of sub-optimal GPA on ageing.

Field of science

  • /medical and health sciences/basic medicine/physiology/homeostasis

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

OULUN YLIOPISTO
Address
Pentti Kaiteran Katu 1
90014 Oulu
Finland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 877 663,14

Participants (13)

BETA TECHNOLOGY LTD
United Kingdom
EU contribution
€ 250 336
Address
Barclay Court, Doncaster Carr
DN4 5HZ Doncaster
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SAMFUNDET FOLKHALSAN I SVENSKA FINLAND RF
Finland
EU contribution
€ 495 366,25
Address
Topeliusgatan 20
00250 Helsinki
Activity type
Research Organisations
REGION HOVEDSTADEN
Denmark
EU contribution
€ 368 527,98
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 322 450
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 640 501
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 568 907,15
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 372 453,75
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE GRANADA
Spain
EU contribution
€ 555 990
Address
Cuesta Del Hospicio Sn
18071 Granada
Activity type
Higher or Secondary Education Establishments
LABORATORIOS ORDESA SL
Spain
EU contribution
€ 15 660
Address
Carretera Del Prat 9-11
08830 Sant Boi De Llobregat
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ABBOTT LABORATORIES SA
Spain
EU contribution
€ 78 160
Address
Avenida De Burgos 91
28050 Madride
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 720 160
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 625 000
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
BRUNEL UNIVERSITY LONDON
United Kingdom
EU contribution
€ 26 090,23
Address
Kingston Lane
UB8 3PH Uxbridge
Activity type
Higher or Secondary Education Establishments