Skip to main content

Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging

Objective

The Gluco-Psychosocial Axis (GPA) concerns the interplay of factors determining glucose metabolism and insulin sensitivity and the neuroendocrine response resulting from exposure to psychosocial stress. A sub-optimal GPA influences the development of type 2 diabetes and related impairments with varying degrees of interplay between genetics and early growth (particularly adiposity and cognitive function), and social, occupational, and other modifiable lifestyle factors. Many exposures apply from throughout life, and potential exposure to a sub-optimal GPA lead to a cumulative risk of ill health and decreased economic prospects for the ageing. Understanding these factors, interactions and extent they contribute to the preservation of glucose homeostasis and psychosocial functioning is important for the development of preventive and therapeutic measures promoting healthy and active ageing. DynaHEALTH will contribute to implementing a dynamic model for early GPA risk identification and validation, allowing development of risk-based prevention tools and policies that will help to inform policy makers on the best periods to invest in cost-effective and sustainable healthcare strategies. DynaHEALTH comprises 13 partners from academic/private sectors and will leverage data from 21 birth cohorts and intervention studies, involving 1.5 million Europeans. By identifying biological and psychosocial determinants of the GPA and characterising metabolic and epigenetic factors, whilst quantifying the impact of exposure to an optimal lifelong GPA, DynaHEALTH will influence weight gain, glucose homeostasis, employability, health deterioration and disease accumulation as individuals age. DynaHEALTH includes the potential to exploit the results for new technologies and strategies, adding to our understanding of pathways related to healthy and active ageing, underpinning options for targeted, personalised healthcare and mitigating the effects of sub-optimal GPA on ageing.

Call for proposal

H2020-PHC-2014-2015

See other projects for this call

Sub call

H2020-PHC-2014-two-stage

Coordinator

OULUN YLIOPISTO
Net EU contribution
€ 877 663,14
Address
Pentti Kaiteran Katu 1
90014 Oulu
Finland

See on map

Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa
Activity type
Higher or Secondary Education Establishments
Other funding
€ 877 663,14

Participants (13)

BETA TECHNOLOGY LTD
United Kingdom
Net EU contribution
€ 250 336,00
Address
Barclay Court, Doncaster Carr
DN4 5HZ Doncaster

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Yorkshire and the Humber South Yorkshire Barnsley, Doncaster and Rotherham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 250 336,00
SAMFUNDET FOLKHALSAN I SVENSKA FINLAND RF
Finland
Net EU contribution
€ 495 366,25
Address
Topeliusgatan 20
00250 Helsinki

See on map

Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Research Organisations
Other funding
€ 495 366,25
REGION HOVEDSTADEN
Denmark
Net EU contribution
€ 368 527,98
Address
Kongens Vaenge 2
3400 Hillerod

See on map

Region
Danmark Hovedstaden Nordsjælland
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 368 527,98
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
Net EU contribution
€ 322 450,00
Address
Ingolstadter Landstrasse 1
85764 Neuherberg

See on map

Region
Bayern Oberbayern München, Landkreis
Activity type
Research Organisations
Other funding
€ 322 450,00
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Net EU contribution
€ 640 501,00
Address
Geschwister Scholl Platz 1
80539 Muenchen

See on map

Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 640 501,00
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Net EU contribution
€ 568 907,15
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

See on map

Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
€ 568 907,15
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 372 453,75
Address
Gower Street
WC1E 6BT London

See on map

Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
€ 372 453,75
UNIVERSIDAD DE GRANADA
Spain
Net EU contribution
€ 555 990,00
Address
Cuesta Del Hospicio Sn
18071 Granada

See on map

Region
Andalucía Granada
Activity type
Higher or Secondary Education Establishments
Other funding
€ 555 990,00
LABORATORIOS ORDESA SL
Spain
Net EU contribution
€ 15 660,00
Address
Carretera Del Prat 9-11
08830 Sant Boi De Llobregat

See on map

Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 15 660,00
ABBOTT LABORATORIES SA
Spain
Net EU contribution
€ 78 160,00
Address
Avenida De Burgos 91
28050 Madride

See on map

Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 78 160,00
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 720 160,00
Address
Dr Molewaterplein 40
3015 GD Rotterdam

See on map

Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Other funding
€ 720 160,00
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
Net EU contribution
€ 625 000,00
Address
Meibergdreef 15
1105AZ Amsterdam

See on map

Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Other funding
€ 625 000,00
BRUNEL UNIVERSITY LONDON
United Kingdom
Net EU contribution
€ 26 090,23
Address
Kingston Lane
UB8 3PH Uxbridge

See on map

Region
London Outer London — West and North West Harrow and Hillingdon
Activity type
Higher or Secondary Education Establishments
Other funding
€ 26 090,23