Periodic Reporting for period 3 - LIFEPATH (Lifecourse biological pathways underlying social differences in healthy ageing)
Período documentado: 2018-05-01 hasta 2019-04-30
We also addressed potential policy implications, developing some guidelines targeted to different age groups. Our studies showed that early interventions have a critical importance, as their consequences may span the whole life-course. This has important implications for policy making, since appropriate policies can reverse the embodiment of socioeconomic disadvantage, thus reducing health inequalities and resulting in healthier ageing.
For policy purposes, LIFEPATH suggests (a) that the effects of preventive interventions in early life are complementary to interventions in adulthood, (b) that intervening on poor socioeconomic conditions is complementary and quantitatively comparable to well-known risk factors like tobacco and alcohol consumption, obesity or a sedentary lifestyle, and (c) that more needs to be done to attenuate psycho-social factors in addition to material factors.
We studied ACEs and obesity in childhood. Low SEP in early life may shape lifestyle and health-related behaviours, which then affect health in adulthood. In fact, low SEP may be associated with poor early life nutrition; tobacco exposure in utero, infancy and childhood; foetal growth restriction or premature birth. A child’s development is clearly sensitive to the surrounding environment in early childhood and to the availability of sufficient economic resources. Psychosocial stress is also a key factor, since is thought to affect brain development in childhood by affecting glucocorticoid and catecholamine levels which impact executive function, emotional and behavioural control and analytical thinking. Low socioeconomic advantage in childhood may result in educational disadvantage, which in turn drives economic disadvantage in adulthood (Layte, 2017).
LIFEPATH Publications List as of April 2019
1. Berger, E., R. Castagné, M. Chadeau-Hyam, M. Bochud, A. d'Errico, M. Gandini, M. Karimi, M. Kivimäki, V. Krogh, M. Marmot, S. Panico, M. Preisig, F. Ricceri, C. Sacerdote, A. Steptoe, S. Stringhini, R. Tumino, P. Vineis, C. Delpierre, and M. Kelly-Irving. 2019. "Multi-cohort study identifies social determinants of systemic inflammation over the life course." Nat Commun 10 (1):773. doi: 10.1038/s41467-019-08732-x.
2. Castagné, R., V. Garès, M. Karimi, M. Chadeau-Hyam, P. Vineis, C. Delpierre, M. Kelly-Irving, and Lifepath Consortium. 2018. "Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort." Eur J Epidemiol 33 (5):441-458. doi: 10.1007/s10654-018-0364-1.
3. Courtin, E., P. Muennig, N. Verma, J. A. Riccio, M. Lagarde, P. Vineis, I. Kawachi, and M. Avendano. 2018. "Conditional Cash Transfers And Health Of Low-Income Families In The US: Evaluating The Family Rewards Experiment." Health Aff (Millwood) 37 (3):438-446. doi: 10.1377/hlthaff.2017.1271.
4. Kivimäki, M., J. Vahtera, A. G. Tabák, J. I. Halonen, P. Vineis, J. Pentti, K. Pahkala, S. Rovio, J. Viikari, M. Kähönen, M. Juonala, J. E. Ferrie, S. Stringhini, and O. T. Raitakari. 2018. "Neighbourhood socioeconomic disadvantage, risk factors, and diabetes from childhood to middle age in the Young Finns Study: a cohort study." Lancet Public Health 3 (8):e365-e373. doi: 10.1016/S2468-2667(18)30111-7.
5. Mackenbach, J. P., Y. Hu, B. Artnik, M. Bopp, G. Costa, R. Kalediene, P. Martikainen, G. Menvielle, B. H. Strand, B. Wojtyniak, and W. J. Nusselder. 2017. "Trends In Inequalities In Mortality Amenable To Health Care In 17 European Countries." Health Aff (Millwood) 36 (6):1110-1118. doi: 10.1377/hlthaff.2016.1674.
6. Mackenbach, J. P., J. R. Valverde, B. Artnik, M. Bopp, H. Brønnum-Hansen, P. Deboosere, R. Kalediene, K. Kovács, M. Leinsalu, P. Martikainen, G. Menvielle, E. Regidor, J. Rychtaříková, M. Rodriguez-Sanz, P. Vineis, C. White, B. Wojtyniak, Y. Hu, and W. J. Nusselder. 2018. "Trends in health inequalities in 27 European countries." Proc Natl Acad Sci U S A 115 (25):6440-6445. doi: 10.1073/pnas.1800028115.
7. Stringhini, S., C. Carmeli, M. Jokela, M. Avendaño, C. McCrory, A. d'Errico, M. Bochud, H. Barros, G. Costa, M. Chadeau-Hyam, C. Delpierre, M. Gandini, S. Fraga, M. Goldberg, G. G. Giles, C. Lassale, R. A. Kenny, M. Kelly-Irving, F. Paccaud, R. Layte, P. Muennig, M. G. Marmot, A. I. Ribeiro, G. Severi, A. Steptoe, M. J. Shipley, M. Zins, J. P. Mackenbach, P. Vineis, M. Kivimäki, and LIFEPATH Consortium. 2018. "Socioeconomic status, non-communicable disease risk factors, and walking speed in older adults: multi-cohort population based study." BMJ 360:k1046. doi: 10.1136/bmj.k1046.
8. Stringhini, S., C. Carmeli, M. Jokela, M. Avendaño, P. Muennig, F. Guida, F. Ricceri, A. d'Errico, H. Barros, M. Bochud, M. Chadeau-Hyam, F. Clavel-Chapelon, G. Costa, C. Delpierre, S. Fraga, M. Goldberg, G. G. Giles, V. Krogh, M. Kelly-Irving, R. Layte, A. M. Lasserre, M. G. Marmot, M. Preisig, M. J. Shipley, P. Vollenweider, M. Zins, I. Kawachi, A. Steptoe, J. P. Mackenbach, P. Vineis, M. Kivimäki, and LIFEPATH consortium. 2017. "Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women." Lancet 389 (10075):1229-1237. doi: 10.1016/S0140-6736(16)32380-7.