Objective The project aims at diagnosing oral and respiratory tract infections (RTIs) using a fully integrated, automated and user-friendly platform for physicians’ offices, schools, elderly care units, community settings, etc. Oral diseases (periodontitis, caries) will be detected via multiplexed, quantitative analysis of salivary markers (bacterial DNA and host response proteins) for early prevention and personalized monitoring. RTIs (e.g. tonsillitis, pharyngitis, rhinitis, sinusitis) will be diagnosed by means of DNA/RNA differentiation so as to identify their bacterial vs viral nature. Together with antibiotic resistance screening on the same platform, a more efficient treatment management is expected at the point-of-care. High impact is expected on socioeconomic level too, as the healthcare system is expected to benefit from: less crowded hospitals (patients find equally efficient chair-side diagnosis); less budget spent on excessive antibiotics and progressed-stage disease treatments; less insurance costs for oral diseases, which are largely age-related. At the heart of DIAGORAS lies a centrifugal microfluidic platform (LabDisk and associated reader) integrating all components and assays for a fully-automated analysis: interface of the collection tube with the disposable disc; on-disc sample preparation (nucleic acid extraction and purification with pre-stored buffers); amplification & detection (rapid PCR); protein isolation and detection (bead-based multiplexed immunoassays); microarray-based antibiotic screening. Low-cost disposable fabrication (microthermoforming of polymer foils) will render the platform batch-producible and affordable to end users. The entire setup will be validated at clinical settings and compared with gold standards (e.g. tissue extraction and culture methods). The modular nature of the platform, the non-invasive sampling, the rapid and multiplexed molecular-based detection, and the sample-to-answer analysis are DIAGORAS innovative features. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acidsmedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsmedical and health sciencesclinical medicineodontologyperiodonticsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Keywords antibiotic resistance caries centrifugal microfluidics diagnostics lab-on-a-chip multiplexing periodontitis point-of-care quality control respiratory tract infections saliva Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.3. - Treating and managing disease Topic(s) PHC-10-2014 - Development of new diagnostic tools and technologies: in vitro devices, assays and platforms Call for proposal H2020-PHC-2014-2015 See other projects for this call Sub call H2020-PHC-2014-two-stage Funding Scheme RIA - Research and Innovation action Coordinator HAHN-SCHICKARD-GESELLSCHAFT FUR ANGEWANDTE FORSCHUNG EV Net EU contribution € 985 378,50 Address WILHELM SCHICKARD STRASSE 10 78052 Villingen Schwenning Germany See on map Region Baden-Württemberg Freiburg Schwarzwald-Baar-Kreis Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 985 378,75 Participants (10) Sort alphabetically Sort by Net EU contribution Expand all Collapse all AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH Austria Net EU contribution € 749 531,25 Address GIEFINGGASSE 4 1210 Wien See on map Region Ostösterreich Wien Wien Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 749 531,25 UNIVERSITAT ZURICH Switzerland Net EU contribution € 0,00 Address RAMISTRASSE 71 8006 Zurich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 823 152,50 ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands Net EU contribution € 819 016,25 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 819 016,25 Askion GmbH Germany Net EU contribution € 499 250,00 Address GEWERBEPARK KEPLERSTRASSE 17-19 07549 Gera See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Thüringen Thüringen Gera, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 499 250,00 MAGNAMEDICS DIAGNOSTICS BV Participation ended Netherlands Net EU contribution € 398 317,50 Address DE ASSELEN KUIL 12 6161 RD Geleen See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 398 317,50 CLINICAGENO LIMITED United Kingdom Net EU contribution € 436 208,75 Address STATION APPROACH 11 COULSDON NORTH CR5 2NR Coulsdon Surrey See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region London Outer London — South Croydon Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 436 208,75 BIOVENDOR - LABORATORNI MEDICINA AS Czechia Net EU contribution € 625 308,75 Address KARASEK 1767/1 621 00 Brno See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Česko Jihovýchod Jihomoravský kraj Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 625 308,75 SPARKS & CO Participation ended France Net EU contribution € 121 563,75 Address 66 AVENUE DES CHAMPS ELYSEES ESPACE 41 75008 Paris See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 121 563,75 KAROLINSKA INSTITUTET Sweden Net EU contribution € 16 191,25 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 59 941,25 MAGTIVIO B.V. Netherlands Net EU contribution € 70 432,50 Address VLOTSTRAT 2-4 6417 CB Heerlen See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 70 432,50
