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Chair/bedside diagnosis of oral and respiratory tract infections, and identification of antibiotic resistances for personalised monitoring and treatment

Objective

The project aims at diagnosing oral and respiratory tract infections (RTIs) using a fully integrated, automated and user-friendly platform for physicians’ offices, schools, elderly care units, community settings, etc. Oral diseases (periodontitis, caries) will be detected via multiplexed, quantitative analysis of salivary markers (bacterial DNA and host response proteins) for early prevention and personalized monitoring. RTIs (e.g. tonsillitis, pharyngitis, rhinitis, sinusitis) will be diagnosed by means of DNA/RNA differentiation so as to identify their bacterial vs viral nature. Together with antibiotic resistance screening on the same platform, a more efficient treatment management is expected at the point-of-care. High impact is expected on socioeconomic level too, as the healthcare system is expected to benefit from: less crowded hospitals (patients find equally efficient chair-side diagnosis); less budget spent on excessive antibiotics and progressed-stage disease treatments; less insurance costs for oral diseases, which are largely age-related. At the heart of DIAGORAS lies a centrifugal microfluidic platform (LabDisk and associated reader) integrating all components and assays for a fully-automated analysis: interface of the collection tube with the disposable disc; on-disc sample preparation (nucleic acid extraction and purification with pre-stored buffers); amplification & detection (rapid PCR); protein isolation and detection (bead-based multiplexed immunoassays); microarray-based antibiotic screening. Low-cost disposable fabrication (microthermoforming of polymer foils) will render the platform batch-producible and affordable to end users. The entire setup will be validated at clinical settings and compared with gold standards (e.g. tissue extraction and culture methods). The modular nature of the platform, the non-invasive sampling, the rapid and multiplexed molecular-based detection, and the sample-to-answer analysis are DIAGORAS innovative features.

Call for proposal

H2020-PHC-2014-two-stage
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Coordinator

HAHN-SCHICKARD-GESELLSCHAFT FUR ANGEWANDTE FORSCHUNG EV
Address
Wilhelm Schickard Strasse 10
78052 Villingen Schwenning
Germany

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Activity type
Research Organisations
EU contribution
€ 985 378,50

Participants (10)

AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Austria
EU contribution
€ 749 531,25
Address
Giefinggasse 4
1210 Wien

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Activity type
Research Organisations
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 0
Address
Ramistrasse 71
8006 Zurich

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Activity type
Higher or Secondary Education Establishments
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 819 016,25
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Activity type
Higher or Secondary Education Establishments
Askion GmbH
Germany
EU contribution
€ 499 250
Address
Gewerbepark Keplerstrasse 17-19
07549 Gera

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MAGNAMEDICS DIAGNOSTICS BV

Participation ended

Netherlands
EU contribution
€ 398 317,50
Address
De Asselen Kuil 12
6161 RD Geleen

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CLINICAGENO LIMITED
United Kingdom
EU contribution
€ 436 208,75
Address
Station Approach 11 Coulsdon North
CR5 2NR Coulsdon Surrey

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOVENDOR - LABORATORNI MEDICINA AS
Czechia
EU contribution
€ 625 308,75
Address
Karasek 1767/1
621 00 Brno

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SPARKS & CO

Participation ended

France
EU contribution
€ 121 563,75
Address
66 Avenue Des Champs Elysees Espace 41
75008 Paris

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 16 191,25
Address
Nobels Vag 5
17177 Stockholm

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Activity type
Higher or Secondary Education Establishments
MAGTIVIO B.V.
Netherlands
EU contribution
€ 70 432,50
Address
Vlotstrat 2-4
6417 CB Heerlen

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)