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Chair/bedside diagnosis of oral and respiratory tract infections, and identification of antibiotic resistances for personalised monitoring and treatment

Objective

The project aims at diagnosing oral and respiratory tract infections (RTIs) using a fully integrated, automated and user-friendly platform for physicians’ offices, schools, elderly care units, community settings, etc. Oral diseases (periodontitis, caries) will be detected via multiplexed, quantitative analysis of salivary markers (bacterial DNA and host response proteins) for early prevention and personalized monitoring. RTIs (e.g. tonsillitis, pharyngitis, rhinitis, sinusitis) will be diagnosed by means of DNA/RNA differentiation so as to identify their bacterial vs viral nature. Together with antibiotic resistance screening on the same platform, a more efficient treatment management is expected at the point-of-care. High impact is expected on socioeconomic level too, as the healthcare system is expected to benefit from: less crowded hospitals (patients find equally efficient chair-side diagnosis); less budget spent on excessive antibiotics and progressed-stage disease treatments; less insurance costs for oral diseases, which are largely age-related. At the heart of DIAGORAS lies a centrifugal microfluidic platform (LabDisk and associated reader) integrating all components and assays for a fully-automated analysis: interface of the collection tube with the disposable disc; on-disc sample preparation (nucleic acid extraction and purification with pre-stored buffers); amplification & detection (rapid PCR); protein isolation and detection (bead-based multiplexed immunoassays); microarray-based antibiotic screening. Low-cost disposable fabrication (microthermoforming of polymer foils) will render the platform batch-producible and affordable to end users. The entire setup will be validated at clinical settings and compared with gold standards (e.g. tissue extraction and culture methods). The modular nature of the platform, the non-invasive sampling, the rapid and multiplexed molecular-based detection, and the sample-to-answer analysis are DIAGORAS innovative features.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2014-two-stage

Coordinator

HAHN-SCHICKARD-GESELLSCHAFT FUR ANGEWANDTE FORSCHUNG EV
Net EU contribution
€ 985 378,50
Address
Wilhelm Schickard Strasse 10
78052 Villingen Schwenning
Germany

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Region
Baden-Württemberg Freiburg Schwarzwald-Baar-Kreis
Activity type
Research Organisations
Other funding
€ 0,25

Participants (10)

AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Austria
Net EU contribution
€ 749 531,25
Other funding
€ 0,00
UNIVERSITAT ZURICH
Switzerland
Net EU contribution
€ 0,00
Address
Ramistrasse 71
8006 Zurich

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Other funding
€ 823 152,50
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 819 016,25
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Askion GmbH
Germany
Net EU contribution
€ 499 250,00
Address
Gewerbepark Keplerstrasse 17-19
07549 Gera

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Thüringen Thüringen Gera, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
MAGNAMEDICS DIAGNOSTICS BV

Participation ended

Netherlands
Net EU contribution
€ 398 317,50
Address
De Asselen Kuil 12
6161 RD Geleen
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Limburg (NL) Zuid-Limburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
CLINICAGENO LIMITED
United Kingdom
Net EU contribution
€ 436 208,75
Address
Station Approach 11 Coulsdon North
CR5 2NR Coulsdon Surrey

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
London Outer London — South Croydon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
BIOVENDOR - LABORATORNI MEDICINA AS
Czechia
Net EU contribution
€ 625 308,75
Address
Karasek 1767/1
621 00 Brno

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Jihovýchod Jihomoravský kraj
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
SPARKS & CO

Participation ended

France
Net EU contribution
€ 121 563,75
Address
66 Avenue Des Champs Elysees Espace 41
75008 Paris
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 16 191,25
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 43 750,00
MAGTIVIO B.V.
Netherlands
Net EU contribution
€ 70 432,50
Address
Vlotstrat 2-4
6417 CB Heerlen

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Region
Limburg (NL) Zuid-Limburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00