Novel Stromal Cell Therapy for Diabetic Kidney Disease

Project Information

NEPHSTROM

Grant agreement ID: 634086

DOI 10.3030/634086

Project closed

EC signature date 8 April 2015

Start date 1 May 2015

End date 31 October 2021

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 5 994 373,75

EU contribution € 5 994 373,75

Coordinated by

UNIVERSITY OF GALWAY
Ireland

Deliverables

Websites, patent fillings, videos etc. (2)

Dissemination materials

Dissemination materials brochure flyer posters newsletters

Website

Website updated throughout the project

Documents, reports (1)

Publishable Final Report

Publications

Peer reviewed articles (23)

Effects of mesenchymal stromal cells on regulatory T cells: Current understanding and clinical relevance

Author(s): Neema Negi, Matthew D. Griffin
Published in: STEM CELLS, Issue 38/5, 2020, Page(s) 596-605, ISSN 1066-5099
Publisher: AlphaMed Press Inc
DOI: 10.1002/stem.3151

Mesenchymal stromal cell–based therapies for acute kidney injury: progress in the last decade

Author(s): Barbara Fazekas, Matthew D. Griffin
Published in: Kidney International, Issue 97/6, 2020, Page(s) 1130-1140, ISSN 0085-2538
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2019.12.019

The impact of chronic kidney disease on developed countries from a health economics perspective: A systematic scoping review

Author(s): Sarah Elshahat, Paul Cockwell, Alexander P. Maxwell, Matthew Griffin, Timothy O’Brien, Ciaran O’Neill
Published in: PLOS ONE, Issue 15/3, 2020, Page(s) e0230512, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0230512

Burden of chronic kidney disease and rapid decline in renal function among adults attending a hospital-based diabetes center in Northern Europe

Author(s): Tomás P Griffin, Paula M O'Shea, Andrew Smyth, Md Nahidul Islam, Deirdre Wall, John Ferguson, Esther O'Sullivan, Francis M Finucane, Sean F Dinneen, Fidelma P Dunne, David W Lappin, Donal N Reddan, Marcia Bell, Timothy O'Brien, Damian G Griffin, Matthew D Griffin
Published in: BMJ Open Diabetes Research & Care, Issue 9/1, 2021, Page(s) e002125, ISSN 2052-4897
Publisher: BMJ Open Diabetes Research and Care
DOI: 10.1136/bmjdrc-2021-002125

Chronic kidney disease

Author(s): Paola Romagnani, Giuseppe Remuzzi, Richard Glassock, Adeera Levin, Kitty J. Jager, Marcello Tonelli, Ziad Massy, Christoph Wanner, Hans-Joachim Anders
Published in: Nature Reviews Disease Primers, Issue 3, 2017, Page(s) 17088, ISSN 2056-676X
Publisher: Nature Reviews
DOI: 10.1038/nrdp.2017.88

Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?

Author(s): Paul Lohan, Oliver Treacy, Matthew D. Griffin, Thomas Ritter, Aideen E. Ryan
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.01626

Influence of Referral to a Combined Diabetology and Nephrology Clinic on Renal Functional Trends and Metabolic Parameters in Adults With Diabetic Kidney Disease

Author(s): William P. Martin, Tomás P. Griffin, David W. Lappin, Damian G. Griffin, John P. Ferguson, Timothy O'Brien, Matthew D. Griffin
Published in: Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Issue 1/2, 2017, Page(s) 150-160, ISSN 2542-4548
Publisher: Elsevier
DOI: 10.1016/j.mayocpiqo.2017.07.003

Interspecies Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat

Author(s): Paul Lohan, Oliver Treacy, Maurice Morcos, Ellen Donohoe, Yvonne O'donoghue, Aideen E. Ryan, Stephen J. Elliman, Thomas Ritter, Matthew D. Griffin
Published in: STEM CELLS, 2018, ISSN 1066-5099
Publisher: AlphaMed Press Inc
DOI: 10.1002/stem.2840

Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death

Author(s): Muhammad Mosaraf Hossain, David Barua, Vahid Arabkari, Nahidul Islam, Ananya Gupta, Sanjeev Gupta
Published in: Oncotarget, Issue 9/14, 2018, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.24451

Anti-donor antibody induction following intramuscular injections of allogeneic mesenchymal stromal cells

Author(s): Senthilkumar Alagesan, Clara Sanz-Nogués, Xizhe Chen, Michael Creane, Thomas Ritter, Rhodri Ceredig, Timothy O'Brien, Matthew D Griffin
Published in: Immunology and Cell Biology, Issue 96/5, 2018, Page(s) 536-548, ISSN 0818-9641
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imcb.12024

Phenotypic and functional heterogeneity of human intermediate monocytes based on HLA-DR expression

Author(s): Eanna P Connaughton, Serika Naicker, Shirley A Hanley, Stephanie M Slevin, John K Eykelenboom, Noel F Lowndes, Timothy O'Brien, Rhodri Ceredig, Matthew D Griffin, Michael C Dennedy
Published in: Immunology and Cell Biology, 2018, ISSN 0818-9641
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imcb.12032

The Promise of Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease

Author(s): Tomás P. Griffin, William Patrick Martin, Nahidul Islam, Timothy O’Brien, Matthew D. Griffin
Published in: Current Diabetes Reports, Issue 16/5, 2016, ISSN 1534-4827
Publisher: Current Science Inc.
DOI: 10.1007/s11892-016-0734-6

Clinical Translation of Mesenchymal Stromal Cell Therapies in Nephrology

Author(s): Norberto Perico, Federica Casiraghi, Giuseppe Remuzzi
Published in: Journal of the American Society of Nephrology, Issue 29/2, 2018, Page(s) 362-375, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/ASN.2017070781

Mesenchymal Stromal Cells for AKI after Cardiac Surgery

Author(s): Norberto Perico, Federica Casiraghi, Giuseppe Remuzzi
Published in: Journal of the American Society of Nephrology, 2018, Page(s) ASN.2017111207, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/ASN.2017111207

The Immune System in Tissue Environments Regaining Homeostasis after Injury: Is “Inflammation” Always Inflammation?

Author(s): Onkar P. Kulkarni, Julia Lichtnekert, Hans-Joachim Anders, Shrikant R. Mulay
Published in: Mediators of Inflammation, Issue 2016, 2016, Page(s) 1-9, ISSN 0962-9351
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2016/2856213

Chronic kidney disease, health-related quality of life and their associated economic burden among a nationally representative sample of community dwelling adults in England

Author(s): Nga T. Q. Nguyen, Paul Cockwell, Alexander P. Maxwell, Matthew Griffin, Timothy O’Brien, Ciaran O’Neill
Published in: PLOS ONE, Issue 13/11, 2018, Page(s) e0207960, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0207960

Defining reference intervals for a serum growth differentiation factor-15 (GDF-15) assay in a Caucasian population and its potential utility in diabetic kidney disease (DKD)

Author(s): Siobhan M. Hamon, Tomás P. Griffin, Md Nahidul Islam, Deirdre Wall, Matthew D. Griffin, Paula M. O’Shea
Published in: Clinical Chemistry and Laboratory Medicine (CCLM), Issue 0/0, 2018, ISSN 1434-6621
Publisher: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/cclm-2018-0534

Effect of Sodium Glucose Co-Transporter-2 Inhibition on the Aldosterone/Renin Ratio in Type 2 Diabetes Mellitus

Author(s): Tomás Griffin, Md Islam, Liam Blake, Marcia Bell, Matthew Griffin, Paula O’Shea
Published in: Hormone and Metabolic Research, Issue 51/02, 2019, Page(s) 91-99, ISSN 0018-5043
Publisher: Georg Thieme Verlag
DOI: 10.1055/a-0794-7026

Allogeneic Mesenchymal Stromal Cells (MSCs) are of Comparable Efficacy to Syngeneic MSCs for Therapeutic Revascularization in C57BKSdb/db Mice Despite the Induction of Alloantibody

Author(s): A. Liew, C. Baustian, D. Thomas, E. Vaughan, C. Sanz-Nogués, M. Creane, X. Chen, S. Alagesan, P. Owens, J. Horan, P. Dockery, M. D. Griffin, A. Duffy, T. O’Brien
Published in: Cell Transplantation, 2018, Page(s) 096368971878486, ISSN 0963-6897
Publisher: Cognizant Communication Corp.
DOI: 10.1177/0963689718784862

Mesenchymal Stromal Cells for Transplant Tolerance

Author(s): Manuel Alfredo Podestà, Giuseppe Remuzzi, Federica Casiraghi
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.01287

Progress toward the clinical application of mesenchymal stromal cells and other disease-modulating regenerative therapies

Author(s): LaTonya J. Hickson, Sandra M. Herrmann, Bairbre A. McNicholas, Matthew D. Griffin
Published in: Kidney360, 2021, Page(s) 10.34067/KID.0005692020, ISSN 2641-7650
Publisher: American Society of Nephrology
DOI: 10.34067/kid.0005692020

Human mesenchymal stromal cells broadly modulate high glucose-induced inflammatory responses of renal proximal tubular cell monolayers

Author(s): Md Nahidul Islam, Tomás P. Griffin, Elizabeth Sander, Stephanie Rocks, Junaid Qazi, Joana Cabral, Jasmin McCaul, Tara McMorrow, Matthew D. Griffin
Published in: Stem Cell Research & Therapy, Issue 10/1, 2019, Page(s) online, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-019-1424-5

Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential

Author(s): Tomás Patrick Griffin, Md Nahidul Islam, Deirdre Wall, John Ferguson, Damian Gerard Griffin, Matthew Dallas Griffin, Paula M. O’Shea
Published in: Scientific Reports, Issue 9/1, 2019, Page(s) online, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-54762-2

Non-peer reviewed articles (1)

Editorial: Innovative Biologics and Drugs to Target Renal Inflammation

Author(s): Matthew D. Griffin, Sundararaman Swaminathan
Published in: Frontiers in Pharmacology, Issue 11, 2020, Page(s) online, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.00038