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Fast Assay for Pathogen Identification and Characterisation

Objective

The emergence of highly diverse resistance mechanisms among pathogens requires their detailed analysis to guarantee an efficient medical treatment. The gold standard in clinical diagnostics is based on the cultivation of bacteria and their phenotypical characterisation. However, these methods are labour-intensive and time-consuming lasting in some cases up to a few weeks. Thus, faster diagnostic techniques are necessary to ensure an immediate and targeted treatment of the patient. DNA-based diagnostics can provide the relevant results within a few hours.
The requirements for a clinical DNA-based characterisation method are high; more than 1000 clinically relevant antibiotic resistance genes, a few hundred phylogenetic marker genes and virulence factors have to be targeted (including SNP detection). The limit of detection has to be low because a few 100 bacterial cells in the blood system can lead to the death of the patient. It should be possible to analyse a wide range of clinical sample origins such as stool, blood, urine and saliva using the same test. In addition, the results have to be obtained within a single working day.
In our project, we will develop two diagnostic systems that can be with direct sample material from patients. Thus, the time-consuming cultivation of pathogens will be avoided. Additionally, the test will be more sensitive, specific and faster than any other test on the market using an innovative DNA probe concept.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2014-two-stage

Coordinator

UNIVERSITE LYON 1 CLAUDE BERNARD
Net EU contribution
€ 531 478,00
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
France

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (10)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 187 500,00
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Austria
Net EU contribution
€ 1 339 696,00
Non-EU contribution
€ 0,00
THE UNIVERSITY OF WARWICK
United Kingdom
Net EU contribution
€ 555 654,00
Address
Kirby Corner Road - University House
CV4 8UW Coventry

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Region
West Midlands (England) West Midlands Coventry
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SVEUCILISTE U ZAGREBU MEDICINSKI FAKULTET
Croatia
Net EU contribution
€ 91 250,00
Address
Salata 3
10 000 Zagreb

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Region
Hrvatska Grad Zagreb Grad Zagreb
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
STICHTING RADBOUD UNIVERSITEIT
Netherlands
Net EU contribution
€ 101 865,00
Address
Houtlaan 4
6525 XZ Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITEIT HASSELT
Belgium
Net EU contribution
€ 315 504,00
Address
Martelarenlaan 42
3500 Hasselt

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Region
Vlaams Gewest Prov. Limburg (BE) Arr. Hasselt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AXO SCIENCE SAS
France
Net EU contribution
€ 1 052 675,00
Address
Rue Du Mail 34
69004 Lyon

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
MOLZYM GMBH & CO KG
Germany
Net EU contribution
€ 909 750,00
Address
Mary-astell-strasse 10
28359 Bremen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bremen Bremen Bremen, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
BEE ROBOTICS LTD
United Kingdom
Net EU contribution
€ 770 875,00
Address
Unit 32/33 Cibyn Ind Estate
LL55 2BD Caernarfon

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Wales West Wales and The Valleys Gwynedd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
LYON INGENIERIE PROJETS
France
Net EU contribution
€ 143 750,00
Address
Bd Du 11 Novembre 1918 43 L Atrium
69616 Villeurbanne

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00