OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly

Project Information

OPERAM

Grant agreement ID: 634238

DOI 10.3030/634238

Project closed

EC signature date 7 April 2015

Start date 1 May 2015

End date 30 April 2020

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 3 930 277,25

EU contribution € 3 735 608,25

Coordinated by

UNIVERSITAET BERN
Switzerland

Deliverables

Websites, patent fillings, videos etc. (1)

OPERAM public website opening and flyers

Documents, reports (2)

Ethic Boards' approval obtained to open the trial

Registration number of CT in a WHO- or ICMJE-approved registry

Publications

Peer reviewed articles (20)

Prevalence of drug-drug interactions in older people before and after hospital admission: analysis from the OPERAM trial

Author(s): Lorène Zerah, Séverine Henrard, Ingeborg Wilting, Denis O’Mahony, Nicolas Rodondi, Olivia Dalleur, Kieran Dalton, Wilma Knol, Manuel Haschke, Anne Spinewine
Published in: BMC Geriatrics, Issue 21/1, 2021, ISSN 1471-2318
Publisher: BioMed Central
DOI: 10.1186/s12877-021-02532-z

Automatic Extraction of Adverse Drug Reactions from Summary of Product Characteristics

Author(s): Zhengru Shen, Marco Spruit
Published in: Applied Sciences, Issue 11/6, 2021, Page(s) 2663, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app11062663

Frequency and Acceptance of Clinical Decision Support System-Generated STOPP/START Signals for Hospitalised Older Patients with Polypharmacy and Multimorbidity

Author(s): Bastiaan T. G. M. Sallevelt, Corlina J. A. Huibers, Jody M. J. Op Heij, Toine C. G. Egberts, Eugène P. van Puijenbroek, Zhengru Shen, Marco R. Spruit, Katharina Tabea Jungo, Nicolas Rodondi, Olivia Dalleur, Anne Spinewine, Emma Jennings, Denis O’Mahony, Ingeborg Wilting & Wilma Knol
Published in: Drugs & Aging, Issue 39, 2022, Page(s) 59-73, ISSN 1179-1969
Publisher: Adis International Ltd
DOI: 10.1007/s40266-021-00904-z

An International Consensus List of Potentially Clinically Significant Drug-Drug Interactions in Older People

Author(s): Pauline Anrys, Anne-Elisabeth Petit, Stefanie Thevelin, Bastiaan Sallevelt, Clara Drenth, Roy L. Soiza, Andrea Correa-Pérez, Olivia Dalleur, Isabelle De Brauwer, Mirko Petrovic, Jamie J. Coleman, Kieran Dalton, Denis O'Mahony, Axel Löwe, Silvan Thürig, Aðalsteinn Gudmundsson, Antonio Cherubini, Agapios Panos, Dimitris Mavridis, Nicolas Rodondi, Anne Spinewine
Published in: Journal of the American Medical Directors Association, 2021, ISSN 1525-8610
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1016/j.jamda.2021.03.019

Cross-sectional study on the prevalence of influenza and pneumococcal vaccination and its association with health conditions and risk factors among hospitalized multimorbid older patients

Author(s): Dimitrios David Papazoglou, Oliver Baretella, Martin Feller, Cinzia Del Giovane, Elisavet Moutzouri, Drahomir Aujesky, Matthias Schwenkglenks, Denis O’Mahony, Wilma Knol, Olivia Dalleur, Nicolas Rodondi, Christine Baumgartner
Published in: PLOS ONE, Issue 16/11, 2021, Page(s) e0260112, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0260112

Measurement properties of EQ-5D-3L and EQ-5D-5L in recording self-reported health status in older patients with substantial multimorbidity and polypharmacy

Author(s): Arjun Bhadhuri, Paul Kind, Paola Salari, Katharina Tabea Jungo, Benoît Boland, Stephen Byrne, Stefanie Hossmann, Olivia Dalleur, Wilma Knol, Elisavet Moutzouri, Denis O’Mahony, Kevin D. Murphy, Linda Wisselink, Nicolas Rodondi, Matthias Schwenkglenks
Published in: Health and Quality of Life Outcomes, Issue 18/1, 2020, ISSN 1477-7525
Publisher: BioMed Central
DOI: 10.1186/s12955-020-01564-0

International core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy

Author(s): Jean-Baptiste Beuscart, Wilma Knol, Shane Cullinan, Claudio Schneider, Olivia Dalleur, Benoit Boland, Stefanie Thevelin, Paul A. F. Jansen, Denis O’Mahony, Nicolas Rodondi, Anne Spinewine
Published in: BMC Medicine, Issue 16/1, 2018, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-018-1007-9

Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study

Author(s): O Riordan, David; Aubert, Carole Elodie; Walsh, Kieran A; Van Dorland, Anette; Rodondi, Nicolas; Du Puy, Robert S; Poortvliet, Rosalinde K E; Gussekloo, Jacobijn; Sinnott, Carol; Byrne, Stephen; Galvin, Rose; Jukema, J Wouter; Mooijaart, Simon P; Baumgartner, Christine; McCarthy, Vera; Walsh, Elaine K; Collet, Tinh-Hai; Dekkers, Olaf M; Blum, Manuel R; Kearney, Patricia M
Published in: BMJ Open, Issue 8, 2018, Page(s) 1-10, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.17863/CAM.24741

A systematic review of the outcomes reported in trials of medication review in older patients: the need for a core outcome set

Author(s): Jean-Baptiste Beuscart, Lisa G. Pont, Stefanie Thevelin, Benoit Boland, Olivia Dalleur, Anne W. S. Rutjes, Johanna I. Westbrook, Anne Spinewine
Published in: British Journal of Clinical Pharmacology, Issue 83/5, 2017, Page(s) 942-952, ISSN 0306-5251
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bcp.13197

Additional considerations are required when preparing a protocol for a systematic review with multiple interventions.

Author(s): Chaimani, Anna; Caldwell, Deborah M; Li, Tianjing; Higgins, Julian Pt; Salanti, Georgia
Published in: Journal of clinical epidemiology, Issue 83, 2017, Page(s) 65-74, ISSN 0895-4356
Publisher: Elsevier BV
DOI: 10.7892/boris.94317

A comparison of 20 heterogeneity variance estimators in statistical synthesis of results from studies: a simulation study

Author(s): Maria Petropoulou, Dimitris Mavridis
Published in: Statistics in Medicine, Issue 36/27, 2017, Page(s) 4266-4280, ISSN 0277-6715
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/sim.7431

Development of a standardized chart review method to identify drug-related hospital admissions in older people

Author(s): Stefanie Thevelin, Anne Spinewine, Jean-Baptiste Beuscart, Benoit Boland, Sophie Marien, Fanny Vaillant, Ingeborg Wilting, Ariel Vondeling, Carmen Floriani, Claudio Schneider, Jacques Donzé, Nicolas Rodondi, Shane Cullinan, Denis O'Mahony, Olivia Dalleur
Published in: British Journal of Clinical Pharmacology, Issue 84/11, 2018, Page(s) 2600-2614, ISSN 0306-5251
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bcp.13716

Identification of behaviour change techniques in deprescribing interventions: a systematic review and meta-analysis

Author(s): Christina R. Hansen, Denis O'Mahony, Patricia M. Kearney, Laura J. Sahm, Shane Cullinan, C.J.A. Huibers, Stefanie Thevelin, Anne W.S. Rutjes, Wilma Knol, Sven Streit, Stephen Byrne
Published in: British Journal of Clinical Pharmacology, Issue 84/12, 2018, Page(s) 2716-2728, ISSN 0306-5251
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bcp.13742

A Systematic Review of Open Source Clinical Software on GitHub for Improving Software Reuse in Smart Healthcare

Author(s): Zhengru Shen, Marco Spruit
Published in: Applied Sciences, Issue 9/1, 2019, Page(s) 150, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app9010150

Rationale and design of OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM): a cluster randomised controlled trial

Author(s): Luise Adam, Elisavet Moutzouri, Christine Baumgartner, Axel Lennart Loewe, Martin Feller, Khadija M’Rabet-Bensalah, Nathalie Schwab, Stefanie Hossmann, Claudio Schneider, Sabrina Jegerlehner, Carmen Floriani, Andreas Limacher, Katharina Tabea Jungo, Corlina Johanna Alida Huibers, Sven Streit, Matthias Schwenkglenks, Marco Spruit, Anette Van Dorland, Jacques Donzé, Patricia M Kearney, Peter Jün
Published in: BMJ Open, Issue 9:e026769, 2019, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2018-026769

A Lightweight API-Based Approach for Building Flexible Clinical NLP Systems

Author(s): Zhengru Shen, Hugo van Krimpen, Marco Spruit
Published in: Journal of Healthcare Engineering, Issue 2019, 2019, Page(s) 1-11, ISSN 2040-2295
Publisher: Multi Science Publishing
DOI: 10.1155/2019/3435609

Intervention protocol: OPtimising thERapy to prevent avoidable hospital Admission in the Multi-morbid elderly (OPERAM): a structured medication review with support of a computerised decision support system

Author(s): Erin K. Crowley, Bastiaan T. G. M. Sallevelt, Corlina J. A. Huibers, Kevin D. Murphy, Marco Spruit, Zhengru Shen, Benoît Boland, Anne Spinewine, Olivia Dalleur, Elisavet Moutzouri, Axel Löwe, Martin Feller, Nathalie Schwab, Luise Adam, Ingeborg Wilting, Wilma Knol, Nicolas Rodondi, Stephen Byrne, Denis O’Mahony
Published in: BMC Health Services Research, Issue 20/1, 2020, ISSN 1472-6963
Publisher: BioMed Central
DOI: 10.1186/s12913-020-5056-3

Interventions for preventing falls and fall‐related fractures in community‐dwelling older adults: A systematic review and network meta‐analysis

Author(s): Lauren Dautzenberg, Shanthi Beglinger, Sofia Tsokani, Stella Zevgiti, Renee C. M. A. Raijmann, Nicolas Rodondi, Rob J. P. M. Scholten, Anne W. S. Rutjes, Marcello Di Nisio, Marielle Emmelot‐Vonk, Andrea C. Tricco, Sharon E. Straus, Sonia Thomas, Lisa Bretagne, Wilma Knol, Dimitris Mavridis, Huiberdina L. Koek
Published in: Journal of the American Geriatrics Society, 2021, ISSN 0002-8614
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jgs.17375

Medication review interventions to reduce hospital readmissions in older people

Author(s): Lauren Dautzenberg, Lisa Bretagne, Huiberdina L. Koek, Sofia Tsokani, Stella Zevgiti, Nicolas Rodondi, Rob J. P. M. Scholten, Anne W. Rutjes, Marcello Di Nisio, Renee C. M. A. Raijmann, Marielle Emmelot‐Vonk, Emma L. M. Jennings, Olivia Dalleur, Dimitris Mavridis, Wilma Knol
Published in: Journal of the American Geriatrics Society, Issue 69/6, 2021, Page(s) 1646-1658, ISSN 0002-8614
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jgs.17041

A review of methods for addressing components of interventions in meta-analysis

Author(s): Maria Petropoulou, Orestis Efthimiou, Gerta Rücker, Guido Schwarzer, Toshi A. Furukawa, Alessandro Pompoli, Huiberdina L. Koek, Cinzia Del Giovane, Nicolas Rodondi, Dimitris Mavridis
Published in: PLOS ONE, Issue 16/2, 2021, Page(s) e0246631, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0246631

Non-peer reviewed articles (1)

Development of a core outcome set for medication review in older patients with multimorbidity and polypharmacy: a study protocol

Author(s): Beuscart, Jean Baptiste; Dalleur, Olivia; Boland, Benoit; Thevelin, Stefanie; Knol, Wilma; Cullinan, Shane; Schneider, Claudio; O'Mahony, Denis; Rodondi, Nicolas; Spinewine, Anne
Published in: Clinical Interventions in Aging, Issue Vo. 12, 2017, Page(s) 1379-1389, ISSN 1178-1998
Publisher: Dove press
DOI: 10.7892/boris.106338

Conference proceedings (1)

A federated information architecture for multinational clinical trials: STRIPA revisited

Author(s): Zhengru Shen, Michiel Meulendijk, Marco Spruit
Published in: 24th European Conference on Information Systems, 2016
Publisher: 24th European Conference on Information Systems