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Novel biocontrol agents for insect pests from neuroendocrinology

Objective

Insects are the most diverse Class of life on earth, and different insects can be essential for, or highly damaging to, agriculture, horticulture and forestry. There is a pressing need, not just for new insecticides to combat resistance, but more specific, “greener” insecticides that target deleterious insects while sparing beneficial ones. This proposal aims to identify such insecticides by turning the insects’ own hormones against them, both by designing artificial neuropeptide “mimetic” analogs as candidate compounds, and by generating transgenic insects that carry deleterious neuropeptide payloads within them, that can propagate through a population and impact on survival at times of stress.

We have assembled an international multi-actor consortium from EU member and associated member states, as well as a third country partner, with unparalleled experience in insect functional genomics, neuropeptide physiology, synthetic chemistry and synthetic biology, and in field-testing of candidates. Established links to agricultural, horticultural and forestry end-users, agencies/advisors and our SME partners ensure relevance to user need; and set out a pathway to exploitation and implementation of our results, for impact across three major economic sectors in the EU and globally.

We will deliver novel, ‘green’ neuropeptide-based insect pest biocontrol tools by:
• utilising ‘beyond the State-of-the-Art’ technologies based on two approaches: rational design of neuropeptide hormone analogues; and development of genetically-encoded neuropeptides for translational insect synthetic biology in genetic pest management.
• bridging outstanding research and technology in neuroendocrinology and genetics to end user need, to ultimately produce neuropeptide hormone analogues and genetic pest management biocontrol tools.
• validating and demonstrating these novel insect biocontrol agents in laboratory, field and forest applications, based on user need and a market-driven approach.

Call for proposal

H2020-SFS-2014-2015

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Sub call

H2020-SFS-2014-2

Coordinator

UNIVERSITY OF GLASGOW
Net EU contribution
€ 2 318 875,00
Address
University Avenue
G12 8QQ Glasgow
United Kingdom

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Region
West Central Scotland Glasgow City
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (13)

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Net EU contribution
€ 530 000,00
Address
Oude Markt 13
3000 Leuven

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITEIT GENT
Belgium
Net EU contribution
€ 511 625,00
Address
Sint Pietersnieuwstraat 25
9000 Gent

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE AGRICULTURAL RESEARCH ORGANISATION OF ISRAEL - THE VOLCANI CENTRE
Israel
Net EU contribution
€ 679 687,50
Address
Derech Hamcabim 68
50250 Bet Dagan

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
STOCKHOLMS UNIVERSITET
Sweden
Net EU contribution
€ 378 406,00
Address
Universitetsvagen 10
10691 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,25
UNIVERSITAT ZU KOLN
Germany
Net EU contribution
€ 442 500,00
Address
Albertus Magnus Platz
50931 Koln

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY OF LEEDS
United Kingdom
Net EU contribution
€ 341 278,50
Address
Woodhouse Lane
LS2 9JT Leeds

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Region
Yorkshire and the Humber West Yorkshire Leeds
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,25
SCOTTISH GOVERNMENT
United Kingdom
Net EU contribution
€ 62 031,00
Address
St Andrews House, Regent Road
EH1 3DG Edinburgh

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Region
Eastern Scotland Edinburgh
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,25
FORESTRY COMMISSION RESEARCH AGENCY
United Kingdom
Net EU contribution
€ 176 481,00
Address
Alice Holt Lodge
GU10 4LH Farnham

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Region
South East (England) Hampshire and Isle of Wight Central Hampshire
Activity type
Research Organisations
Non-EU contribution
€ 0,25
UNIVERSITY OF CAPE TOWN
South Africa
Net EU contribution
€ 62 500,00
Address
Private Bag X3
7701 Rondebosch

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
BRUKER DALTONIK GMBH
Germany
Net EU contribution
€ 438 375,00
Address
Fahrenheitstrasse 4
28359 Bremen

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Region
Bremen Bremen Bremen, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
THE PIRBRIGHT INSTITUTE LBG
United Kingdom
Net EU contribution
€ 719 860,00
Address
Ash Road Pirbright
GU24 0NF Woking

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Region
South East (England) Surrey, East and West Sussex West Surrey
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Oxitec Limited
United Kingdom
Net EU contribution
€ 245 933,50
Address
Miton Park 71
OX14 4RX Oxford

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,25
KNOWLEDGE TRANSFER NETWORK LIMITED
United Kingdom
Net EU contribution
€ 87 500,00
Address
52 Upper Street Suite 218 Business Design Centre Islington
N1 0QH London

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
London Inner London — East Haringey and Islington
Activity type
Other
Non-EU contribution
€ 0,00