Novel biocontrol agents for insect pests from neuroendocrinology

Project Information

nEUROSTRESSPEP

Grant agreement ID: 634361

DOI 10.3030/634361

Project closed

EC signature date 19 February 2015

Start date 1 June 2015

End date 31 May 2019

Funded under

• SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy

Total cost € 6 995 053,75

EU contribution € 6 995 052,50

Coordinated by

UNIVERSITY OF GLASGOW
United Kingdom

Deliverables

Documents, reports (8)

Curated list of conserved and unconserved neuropeptide sequence across our identified species of interest
Publications of key scientific findings from the project and collation of all publications and other dissemination modalities
Final report on dissemination including post-project dissemination activities
Validation of expected, and identification of novel neuropeptides as well as PTMs, in laboratory and pest species

Validation of expected and identification of novel neuropeptides as well as PTMs in laboratory and pest species

Anatomical map of neuropeptide binding sites, across multiple species and multiple peptides, to help delineate mode-of-action

Anatomical map of neuropeptide binding sites across multiple species and multiple peptides to help delineate modeofaction

Plan for communication and dissemination
Impact assessment report
Communications plan (including events and stakeholder management where appropriate)

Communications plan including events and stakeholder management where appropriate

Websites, patent fillings, videos etc. (3)

Comprehensive database of physiological function of selected neuropeptides across model and pest insect species relevant to agriculture, horticulture and forestry

Comprehensive database of physiological function of selected neuropeptides across model and pest insect species relevant to agriculture horticulture and forestry

Deliver outward-facing website and proposal for continuation of website as information portal beyond the lifetime of the project

Deliver outwardfacing website and proposal for continuation of website as information portal beyond the lifetime of the project

Information sheets and video shorts for public and industry end-users

Demonstrators, pilots, prototypes (2)

Neuropeptide metabolomics database for multiple species
Improved methodologies and protocols for fast tissue screening by peptidomics

Publications

Peer reviewed articles (16)

Identification of mature peptides from pban and capa genes of the moths Heliothis peltigera and Spodoptera littoralis

Author(s): Lapo Ragionieri, Burak Özbagci, Susanne Neupert, Yuval Salts, Michael Davidovitch, Miriam Altstein, Reinhard Predel
Published in: Peptides, Issue 94, 2017, Page(s) 1-9, ISSN 0196-9781
Publisher: Elsevier BV
DOI: 10.1016/j.peptides.2017.05.004

DINeR: Database for Insect Neuropeptide Research

Author(s): Joseph G.C. Yeoh, Aniruddha A. Pandit, Meet Zandawala, Dick R. Nässel, Shireen-Anne Davies, Julian A.T. Dow
Published in: Insect Biochemistry and Molecular Biology, Issue 86, 2017, Page(s) 9-19, ISSN 0965-1748
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ibmb.2017.05.001

Analysis of Peptide Ligand Specificity of Different Insect Adipokinetic Hormone Receptors

Author(s): Elisabeth Marchal, Sam Schellens, Emilie Monjon, Evert Bruyninckx, Heather Marco, Gerd Gäde, Jozef Vanden Broeck, Heleen Verlinden
Published in: International Journal of Molecular Sciences, Issue 19/2, 2018, Page(s) 542, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19020542

Peptidergic control in a fruit crop pest: The spotted-wing drosophila, Drosophila suzukii

Author(s): Caroline S. Gough, Grace M. Fairlamb, Petra Bell, Ronald J. Nachman, Neil Audsley, R. Elwyn Isaac
Published in: PLOS ONE, Issue 12/11, 2017, Page(s) e0188021, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0188021

nEUROSTRESSPEP: Novel biocontrol agents for insect pests from neuroendocrinology

Author(s): Shireen Davies
Published in: International Pest Control, Issue 59(3):164-165, 2017, Page(s) 164-165, ISSN 0020-8256
Publisher: Research Information Ltd.

Renal neuroendocrine control of desiccation and cold tolerance by Drosophila suzukii

Author(s): Selim Terhzaz, Lucy Alford, Joseph GC Yeoh, Richard Marley, Anthony J Dornan, Julian AT Dow, Shireen A Davies
Published in: Pest Management Science, Issue 74/4, 2018, Page(s) 800-810, ISSN 1526-498X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ps.4663

Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila

Author(s): Meet Zandawala, Richard Marley, Shireen A. Davies, Dick R. Nässel
Published in: Cellular and Molecular Life Sciences, Issue 75/6, 2018, Page(s) 1099-1115, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-017-2682-y

The corticotropin-releasing factor-like diuretic hormone 44 (DH 44 ) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster

Author(s): Elizabeth Cannell, Anthony J. Dornan, Kenneth A. Halberg, Selim Terhzaz, Julian A.T. Dow, Shireen-A. Davies
Published in: Peptides, Issue 80, 2016, Page(s) 96-107, ISSN 0196-9781
Publisher: Elsevier BV
DOI: 10.1016/j.peptides.2016.02.004

Enhanced Coverage of Insect Neuropeptides in Tissue Sections by an Optimized Mass-Spectrometry-Imaging Protocol

Author(s): Alice Ly, Lapo Ragionieri, Sander Liessem, Michael Becker, Sören-Oliver Deininger, Susanne Neupert, Reinhard Predel
Published in: Analytical Chemistry, Issue 91/3, 2019, Page(s) 1980-1988, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.8b04304

Assessment of neuropeptide binding sites and the impact of biostable kinin and CAP2b analogue treatment on aphid ( Myzus persicae and Macrosiphum rosae ) stress tolerance

Author(s): Lucy Alford, Richard Marley, Anthony Dornan, Jean‐Sébastien Pierre, Julian AT Dow, Ronald J Nachman, Shireen A Davies
Published in: Pest Management Science, Issue 75/6, 2019, Page(s) 1750-1759, ISSN 1526-498X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ps.5372

Coordinated RNA-Seq and peptidomics identify neuropeptides and G-protein coupled receptors (GPCRs) in the large pine weevil Hylobius abietis, a major forestry pest

Author(s): Aniruddha A. Pandit, Lapo Ragionieri, Richard Marley, Joseph G.C. Yeoh, Daegan J.G. Inward, Shireen-Anne Davies, Reinhard Predel, Julian A.T. Dow
Published in: Insect Biochemistry and Molecular Biology, Issue 101, 2018, Page(s) 94-107, ISSN 0965-1748
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ibmb.2018.08.003

Desiccation, thermal stress and associated mortality in Drosophila fruit flies induced by neuropeptide analogue treatment

Author(s): Lucy Alford, Richard Marley, Anthony Dornan, Julian A. T. Dow, Ronald J. Nachman, Shireen A. Davies
Published in: Journal of Pest Science, Issue 92/3, 2019, Page(s) 1123-1137, ISSN 1612-4758
Publisher: Springer Verlag
DOI: 10.1007/s10340-019-01100-0

Peptides in insect oogenesis

Author(s): Cynthia Lenaerts, Emilie Monjon, Joachim Van Lommel, Lina Verbakel, Jozef Vanden Broeck
Published in: Current Opinion in Insect Science, Issue 31, 2019, Page(s) 58-64, ISSN 2214-5745
Publisher: Elsevier BV
DOI: 10.1016/j.cois.2018.08.007

Towards the genetic control of invasive species

Author(s): Tim Harvey-Samuel, Thomas Ant, Luke Alphey
Published in: Biological Invasions, Issue 19/6, 2017, Page(s) 1683-1703, ISSN 1387-3547
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10530-017-1384-6

Modulation of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin

Author(s): Meet Zandawala, Maria E. Yurgel, Michael J. Texada, Sifang Liao, Kim F. Rewitz, Alex C. Keene, Dick R. Nässel
Published in: PLOS Genetics, Issue 14/11, 2018, Page(s) e1007767, ISSN 1553-7404
Publisher: PLOS Genetics
DOI: 10.1371/journal.pgen.1007767

A single pair of leucokinin neurons are modulated by feeding state and regulate sleep–metabolism interactions

Author(s): Maria E. Yurgel, Priyanka Kakad, Meet Zandawala, Dick R. Nässel, Tanja A. Godenschwege, Alex C. Keene
Published in: PLOS Biology, Issue 17/2, 2019, Page(s) e2006409, ISSN 1545-7885
Publisher: PLOS Biology
DOI: 10.1371/journal.pbio.2006409